Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Superoxide Radicals Degradation
Pseudomonas aeruginosa
Category:
Metabolite Pathway
Sub-Category:
Metabolic
Created: 2019-08-12
Last Updated: 2019-08-30
In gram-negative bacteria, cytoplasmic and periplasmic isozymes of superoxide dismutase (SOD) is their defense system against superoxide anion (O2-). In E.coli, there are several SOD isozymes which are manganese-cofactored (MnSOD), iron-cofactored (FeSOD) and copper, zinc-cofactored (CuZnSOD) in perplasm, and they can be generated by autooxidation of dihydromenaquinone in the cytoplasmic membrane. In E.coli, MnSOD and FeSOD have similar structure and kinetic, but CuZnSOD is monomeric. FeSOD is the only SOD in E.coli under anaerobic conditions. MnSOD is induced by environmental stress condition as well as aerobic growth. CuZnSOD is induced in stationary phase. SOD will catalyze the superoxide anion to form oxygen and H2O2. With increasing concentration of H2O2, catalase such as cryptic adenine deaminase is induced in E.coli to degrade H2O2 into water and oxygen.
References
Superoxide Radicals Degradation References
Yan J, Deforet M, Boyle KE, Rahman R, Liang R, Okegbe C, Dietrich LEP, Qiu W, Xavier JB: Bow-tie signaling in c-di-GMP: Machine learning in a simple biochemical network. PLoS Comput Biol. 2017 Aug 2;13(8):e1005677. doi: 10.1371/journal.pcbi.1005677. eCollection 2017 Aug.
Pubmed: 28767643
Hassett DJ, Woodruff WA, Wozniak DJ, Vasil ML, Cohen MS, Ohman DE: Cloning and characterization of the Pseudomonas aeruginosa sodA and sodB genes encoding manganese- and iron-cofactored superoxide dismutase: demonstration of increased manganese superoxide dismutase activity in alginate-producing bacteria. J Bacteriol. 1993 Dec;175(23):7658-65. doi: 10.1128/jb.175.23.7658-7665.1993.
Pubmed: 8244935
Stover CK, Pham XQ, Erwin AL, Mizoguchi SD, Warrener P, Hickey MJ, Brinkman FS, Hufnagle WO, Kowalik DJ, Lagrou M, Garber RL, Goltry L, Tolentino E, Westbrock-Wadman S, Yuan Y, Brody LL, Coulter SN, Folger KR, Kas A, Larbig K, Lim R, Smith K, Spencer D, Wong GK, Wu Z, Paulsen IT, Reizer J, Saier MH, Hancock RE, Lory S, Olson MV: Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen. Nature. 2000 Aug 31;406(6799):959-64. doi: 10.1038/35023079.
Pubmed: 10984043
Polack B, Dacheux D, Delic-Attree I, Toussaint B, Vignais PM: The Pseudomonas aeruginosa fumc and soda genes belong to an iron-responsive operon. Biochem Biophys Res Commun. 1996 Sep 13;226(2):555-60. doi: 10.1006/bbrc.1996.1393.
Pubmed: 8806672
This pathway was propagated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
Propagated from SMP0002066
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Downloads
Settings