Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Aldehyde dehydrogenase X, mitochondrial Peroxisome Solute Transporter Acetaldehyde Transporter Acetaldehyde Mitochondrial Transporter Disulfiram Transporter Disulfiram Plasma Transporter Acetaldehyde Endoplasmic Reticulum Transporter Alcohol dehydrogenase 1B Cytochrome P450 2E1 Catalase Acetyl-coenzyme A synthetase 2-like, mitochondrial Disulfiram Acetyl-CoA Ethanol Ethanol Ethanol Acetaldehyde Acetaldehyde Acetaldehyde Disulfiram Disulfiram Acetaldehyde NAD Acetaldehyde NADH H+ O2 NADPH H2O NADP H2O2 H2O NAD H2O NADH AMP PPi Zinc Heme NADP Citric Acid Cycle Acetic acid H+ ATP CoA Heme Disulfiram is absorbed through the GI tract and enters the cells Disulfiram irreversibly inhibits aldehyde dehydrogenase from coverting acetaldehyde into acetic acid. This causes a build up of acetaldehyde If disulfiram is taken with alcohol consumption the accumulation of acetaldehyde causes unpleasant symptoms of acetaldehyde syndrome (flushing, vasodilation, respiratory difficulties, nausea, hypotension) which deters the individual from drinking alcohol. Cytosol Endoplasmic Reticulum Lumen Peroxisome Mitochondrial Matrix Extracellular Space Hepatocyte
Mitochondria ALDH1B1 Endoplasmic Reticulum Peroxisome Unknown Unknown Unknown Unknown Unknown Unknown ADH1B CYP2E1 CAT ACSS1 Disulfiram Acetyl-CoA Ethanol Ethanol Ethanol Acetaldehyde Acetaldehyde Acetaldehyde Disulfiram Disulfiram Acetaldehyde NAD Acetaldehyde NADH Hydrogen Ion Oxygen NADPH Water NADP Hydrogen peroxide Water NAD Water NADH Adenosine monophosphate Pyrophosphate Citric Acid Cycle Acetic acid Hydrogen Ion Adenosine triphosphate Coenzyme A
ALDH1B1