Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Inosine-5'- monophosphate dehydrogenase 1 Mycophenolic Acid Transporter ADP-sugar pyrophosphatase Ribose- phosphate pyrophosphokinase 3 Amidophosphoribosyltransferase Trifunctional purine biosynthetic protein adenosine-3 Trifunctional purine biosynthetic protein adenosine-3 Phosphoribosylformylglycinamidine synthase Trifunctional purine biosynthetic protein adenosine-3 Multifunctional protein ADE2 Multifunctional protein ADE2 Adenylosuccinate lyase Adenine phosphoribosyltransferase Bifunctional purine biosynthesis protein PURH Bifunctional purine biosynthesis protein PURH Ectonucleoside triphosphate diphosphohydrolase 8 Ectonucleoside triphosphate diphosphohydrolase 8 Nucleoside diphosphate kinase 6 GMP synthase [glutamine- hydrolyzing] Cytosolic purine 5'-nucleotidase Purine nucleoside phosphorylase Mycophenolic acid Inosinic acid Guanosine Guanine Mycophenolic acid Adenosine diphosphate ribose H2O AMP D-Ribose 5-phosphate ATP Phosphoribosyl pyrophosphate AMP 5- Phosphoribosylamine PPi L-Glutamic acid L-Glutamine H2O ATP Glycine ADP Pi Glycineamideribotide 10- Formyltetrahydrofolate Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide ATP L-Glutamine H2O ADP Phosphoric acid Phosphoribosylformylglycineamidine L-Glutamic acid ATP ADP Pi 5- Aminoimidazole ribonucleotide 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate CO2 ATP L-Aspartic acid ADP Phosphoric acid SAICAR Fumaric acid AICAR PPi 5- Aminoimidazole- 4-carboxamide Phosphoribosyl pyrophosphate 10- Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide H2O IDP H2O Pi Inosine triphosphate H2O Pi ATP ADP NAD H2O Xanthylic acid NADH ATP NH3 AMP PPi Guanosine monophosphate H2O Phosphoric acid Pi Ribose 1-phosphate Calcium Adenine and Adenosine Synthesis DNA and RNA Synthesis DNA and RNA Synthesis Potassium Magnesium Magnesium 4Fe-4S Calcium Magnesium Magnesium Cytosol Mycophenolic acid is absorbed in the GI tract and delivered through the blood to the site of action. The plasma protein albumin is important for the movement of the drug as mycophenolic acid binds to albumin. Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase from converting inosinic acid into xanthylic acid. This reaction is the first commited step the purine de novo synthesis pathway to create guanine. Due to the inhibition, low levels or guanine and guanosine are produced halting DNA and RNA synthesis as guanine and gunaosine are important as they are nucleobase and nucleoside respectively. T and B lymphocytes require purines being produced through the purine de novo pathway in order to proliferate and create antibodies. Unlike other cells who can obtain DNA/RNA building blocks through other means, T and B lymphocytes are reliant on this pathway. Mycophenolic acid has potent cytostatic effects causing the immune system to weaken. Lymphocyte
IMPDH1 Unknown NUDT5 PRPS1L1 PPAT GART GART PFAS GART PAICS PAICS ADSL APRT ATIC ATIC ENTPD8 ENTPD8 NME6 GMPS NT5C2 PNP Mycophenolic acid Inosinic acid Guanosine Guanine Mycophenolic acid Adenosine diphosphate ribose Water Adenosine monophosphate D-Ribose 5-phosphate Adenosine triphosphate Phosphoribosyl pyrophosphate Adenosine monophosphate 5- Phosphoribosylamine Pyrophosphate L-Glutamic acid L-Glutamine Water Adenosine triphosphate Glycine Adenosine diphosphate Phosphate Glycineamideribotide 10- Formyltetrahydrofolate Tetrahydrofolic acid 5'- Phosphoribosyl- N- formylglycinamide Adenosine triphosphate L-Glutamine Water Adenosine diphosphate Phosphoric acid Phosphoribosylformylglycineamidine L-Glutamic acid Adenosine triphosphate Adenosine diphosphate Phosphate 5- Aminoimidazole ribonucleotide 5-amino-1-(5- phospho-D- ribosyl)imidazole- 4-carboxylate Carbon dioxide Adenosine triphosphate L-Aspartic acid Adenosine diphosphate Phosphoric acid SAICAR Fumaric acid AICAR Pyrophosphate 5- Aminoimidazole- 4-carboxamide Phosphoribosyl pyrophosphate 10- Formyltetrahydrofolate Tetrahydrofolic acid Phosphoribosyl formamidocarboxamide Water IDP Water Phosphate Inosine triphosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate NAD Water Xanthylic acid NADH Adenosine triphosphate Ammonia Adenosine monophosphate Pyrophosphate Guanosine monophosphate Water Phosphoric acid Phosphate Ribose 1-phosphate Adenine and Adenosine Synthesis DNA and RNA Synthesis DNA and RNA Synthesis
IMPDH1 NUDT5 PRPS1L1 PPAT GART GART PFAS GART PAICS PAICS ADSL APRT ATIC ATIC ENTPD8 ENTPD8 NME6 GMPS NT5C2 PNP Mycophe Imp Guo Guanine Mycophe ADP-Rib H2O AMP DRib-5P ATP PRPP AMP 5-PPRSA PPi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP Gln H2O ADP PhosfrA FGAM Glu ATP ADP Pi 5-AnRbn CR CO2 ATP Asp ADP PhosfrA SAICAR Fumarat AICAR PPi 5Ai4Ca PRPP 10-FTHF THFA FosbFca H2O IDP H2O Pi Ino3P H2O Pi ATP ADP NAD H2O XntylcA NADH ATP NH3 AMP PPi GSMP H2O PhosfrA Pi Rib-1P Ca2+ A a A S D a R S D a R S K+ Mg2+ Mg2+ 4Fe-4S Ca2+ Mg2+ Mg2+ Cytosol Mycophenolic acid is absorbed in the GI tract and delivered through the blood to the site of action. The plasma protein albumin is important for the movement of the drug as mycophenolic acid binds to albumin. Mycophenolic acid inhibits inosine-5'-monophosphate dehydrogenase from converting inosinic acid into xanthylic acid. This reaction is the first commited step the purine de novo synthesis pathway to create guanine. Due to the inhibition, low levels or guanine and guanosine are produced halting DNA and RNA synthesis as guanine and gunaosine are important as they are nucleobase and nucleoside respectively. T and B lymphocytes require purines being produced through the purine de novo pathway in order to proliferate and create antibodies. Unlike other cells who can obtain DNA/RNA building blocks through other means, T and B lymphocytes are reliant on this pathway. Mycophenolic acid has potent cytostatic effects causing the immune system to weaken. Lymphocyte
IMPDH1 NUDT5 PRPS1L1 PPAT GART GART PFAS GART PAICS PAICS ADSL APRT ATIC ATIC ENTPD8 ENTPD8 NME6 GMPS NT5C2 PNP Mycophe Imp Guo Guanine Mycophe ADP-Rib H2O AMP DRib-5P ATP PRPP AMP 5-PPRSA Ppi Glu Gln H2O ATP Gly ADP Pi Glyadbt 10-FTHF THFA 5PPNFG ATP Gln H2O ADP PhosfrA FGAM Glu ATP ADP Pi 5-AnRbn CR CO2 ATP Asp ADP PhosfrA SAICAR Fumarat AICAR Ppi 5Ai4Ca PRPP 10-FTHF THFA FosbFca H2O IDP H2O Pi Ino3P H2O Pi ATP ADP NAD H2O XntylcA NADH ATP NH3 AMP Ppi GSMP H2O PhosfrA Pi Rib-1P A a A S D a R S D a R S