Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Etoposide DNA topoisomerase 2-alpha Canalicular multispecific organic anion transporter 2 Etoposide transporter Etoposide Etoposide Magnesium Cell cycle DNA repair S- DNA replication M- mitosis/ cell division G2- growth, preparation for mitosis and DNA repair DNA strand break G1- cell growth Etoposide forms a complex with DNA and topoisomerase II. It inhibits DNA toposiomerase II. Re-ligation of DNA strand breaks cannot occur since DNA toposiomerase II is non-functional. This leads to errors in DNA synthesis Cancer cell Nucleus Apoptosis Etoposide inhibits the late S phase and the G2 phase of the cell cycle Etoposide enters the cell via the canalicular mutlispecfic organic anion transporter and is transported into the nucleus Errors in DNA synthesis promotes apoptosis of the cancer cell Cytosol
Mitochondria Nucleus Etoposide TOP2A ABCC3 Unknown Etoposide Etoposide