Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Adenosine receptor A2a Adenosine receptor A2b Adenylate Cyclase Adenosine transporter cAMP-specific 3',5'-cyclic phosphodiesterase 4D Adenosine deaminase Prostacyclin receptor Multidrug resistance- associated protein 4 Multidrug resistance- associated protein 4 Prostacyclin transporter Prostaglandin G/H synthase 1 Prostaglandin G/H synthase 2 Thromboxane-A synthase Adenosine Dipyridamole Dipyridamole Prostaglandin I2 Prostaglandin I2 Adenosine Dipyridamole Dipyridamole Dipyridamole Dipyridamole ATP cAMP AMP H2O Inosine NH3 Arachidonic acid Prostaglandin H2 Thromboxane A2 Magnesium Zinc (II) ion Zinc (II) ion Prostacyclin Synthesis Platelet activation and aggregation Platelet Dipyridamole is transported into the platelet cell via multidrug resistance-associated protein 4 Dipyridamole inhibits the adenosine transporter, preventing re-uptake of adenosine from the extracellular space into the cytosol. Dipyridamole inhibits adenosine deaminase which is responsible for adenosine breakdown The concentration of adenosine is high in the extracellular space, leading to increased activation of the adenosine receptors Activation of adenosine receptors activates the Gs signaling cascade which results in increased cAMP porduction. cAMP inhibits platelet activation and aggregation and prevents the release of arachidonic acid from membrane phospholipids Reduced production of thromboxane, which is responsible for platelet activation and aggregation. Endothelial Cell Dipyridamole increases prostacyclin synthesis. More prostacyclin produced. The prostacyclin is transported out of the endothelial cell and acts of prostacyclin receptors on platelets which activates adenylate cyclase. Cytosol Cytosol Extracellular Space
ADORA2A ADORA2B ADCY10 SLC29A1 PDE4D ADA PTGIR ABCC4 ABCC4 Unknown PTGS1 PTGS2 TBXAS1 Adenosine Dipyridamole Dipyridamole Prostaglandin I2 Prostaglandin I2 Adenosine Dipyridamole Dipyridamole Dipyridamole Dipyridamole Adenosine triphosphate cAMP Adenosine monophosphate Water Inosine Ammonia Arachidonic acid Prostaglandin H2 Thromboxane A2 Prostacyclin Synthesis