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Adenylate
cyclase type 10
Protein kinase
A
Protein kinase
A
Protein kinase
A
Protein kinase
A
Protein kinase
A
Chloride anion
exchanger
ATPase Na+/K+
transporting
family member
beta 4
Solute carrier
family 12
member 6
Carbonic
anhydrase 1
Histamine H2
receptor
Guanine
nucleotide-
binding protein
alpha
Gβ
Protein kinase
A
Protein kinase
A
Histamine
cAMP
Cimetidine
H
+
H
+
K
+
K
+
HCO
3
-
HCO
3
-
Cl
-
Cl
-
K
+
K
+
Na
+
Na
+
Cimetidine
Cl
-
Cl
-
K
+
K
+
ATP
H
2
O
CO
2
Hydrochloric acid
Magnesium
Zinc (II) ion
GDP
Potassium-
transporting
ATPase subunit
beta
Potassium-
transporting
ATPase alpha
chain 1
Histamine is released by
nearby enterochromaffin-like
cells in the gastric glands
of the stomach
Cimetidine acts as a
competitive inhibitor on the
H2 receptor and blocks out
the action of histamine on
the receptor which causes
decreased gastric acid
secretion from parietal
cells into the stomach lumen
Parietal Cell
Stomach Lumen
Blood Vessel
The inhibition of the H2
Histamine receptor decreases
the gastric acid response to
food, caffeine, insulin,
betazole, or pentagastrin
Inhibition of H2 histamine
receptors prevents the
activation of adenylate
cyclase, leading to low
concentrations of cAMP which
prevents hydrogen from being
pumped into the lumen
Cimetidine is taken orally
as a tablet
ADCY10
PRKACA
PRKACB
PRKAR1A
PRKAR1B
PRKAR2B
SLC26A3
ATP1B4
SLC12A6
CA1
HRH2
GNAS
GNB1
PRKACG
PRKAR2A
Histamine
cAMP
Cimetidine
Hydrogen Ion
Hydrogen Ion
Potassium
Potassium
Hydrogen
carbonate
Hydrogen
carbonate
Chloride ion
Chloride ion
Potassium
Potassium
Sodium
Sodium
Cimetidine
Chloride ion
Chloride ion
Potassium
Potassium
Adenosine
triphosphate
Water
Carbon dioxide
Hydrochloric
acid
Guanosine
diphosphate
ATP4B
ATP4A