Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Adenylate cyclase type 10 Protein kinase A Protein kinase A Protein kinase A Protein kinase A Protein kinase A Chloride anion exchanger ATPase Na+/K+ transporting family member beta 4 Solute carrier family 12 member 6 Carbonic anhydrase 1 Histamine H2 receptor Guanine nucleotide- binding protein alpha Protein kinase A Protein kinase A Histamine cAMP Metiamide H+ H+ K+ K+ HCO3- HCO3- Cl- Cl- K+ K+ Na+ Na+ Cl- Cl- K+ K+ Metiamide ATP H2O CO2 Hydrochloric acid Magnesium Zinc (II) ion GDP Potassium- transporting ATPase subunit beta Potassium- transporting ATPase alpha chain 1 Histamine is released by nearby enterochromaffin-like cells in the gastric glands of the stomach Metiamide acts as a competitive inhibitor on the H2 receptor and blocks out the action of histamine on the receptor which causes decreased gastric acid secretion from parietal cells into the stomach lumen Parietal Cell Stomach Lumen Blood Vessel The inhibition of the H2 Histamine receptor decreases the gastric acid response to food, caffeine, insulin, betazole, or pentagastrin Inhibition of H2 histamine receptors prevents the activation of adenylate cyclase, leading to low concentrations of cAMP which prevents hydrogen from being pumped into the lumen
ADCY10 PRKACA PRKACB PRKAR1A PRKAR1B PRKAR2B SLC26A3 ATP1B4 SLC12A6 CA1 HRH2 GNAS GNB1 PRKACG PRKAR2A Histamine cAMP Metiamide Hydrogen Ion Hydrogen Ion Potassium Potassium Hydrogen carbonate Hydrogen carbonate Chloride ion Chloride ion Potassium Potassium Sodium Sodium Chloride ion Chloride ion Potassium Potassium Metiamide Adenosine triphosphate Water Carbon dioxide Hydrochloric acid Guanosine diphosphate ATP4B ATP4A