Phenyl glucuronide is a phenolic compound that is formed through gut microbial metabolism from dietary tyrosine and a glucuronidation reaction in liver hepatic cells. After being transported into gut microbes, tyrosine undergoes a reaction with the enzyme tyrosine phenol-lyase to form phenol. Phenol that is produced from the gut microbes then enters systemic circulation. Ultimately phenol undergoes a reaction in a liver hepatocyte through a glucuronosyltransferase enzyme to form Phenyl glucuronide. When this compound returns back into systemic circulation it is shown to be a major uremic toxin through high levels of retention. Phenyl glucuronide is shown to

Metabolism and Physiological Effects of Phenyl glucuronide References