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Pathway Description
Metabolism and Physiological Effects of Putrescine
Homo sapiens
Metabolic Pathway
Created: 2021-04-03
Last Updated: 2023-10-25
Putrescine is an aliphatic amine that is formed through gut microbial metabolism from the amino acid arginine which is acquired from foods that are high in protein. After being transported into gut microbes, arginine undergoes 2 reactions with the enzymes Arginase and Ornithine Decarboxylase to form putrescine. Like other polyamines such as spermidine and spermine, putrescine can also be obtained directly from diet as well. While putrescine is important for interactions and processes involving, DNA, RNA and proteins, at high levels it is also a protein bound uremic toxin found in the body that can inhibit erythropoietin production which can eventually lead to anemia.
References
Metabolism and Physiological Effects of Putrescine References
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Ramos-Molina, B., Queipo-Ortuño, M. I., Lambertos, A., Tinahones, F. J., & Peñafiel, R. (2019). Dietary and gut microbiota polyamines in obesity-and age-related diseases. Frontiers in nutrition, 6, 24.
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Pubmed: 24965220
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