Quantitative metabolomics services for biomarker discovery and validation.
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Insulin Insulin receptor Pyruvate dehydrogenase complex Sodium/potassium ATPase Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 Sodium/potassium ATPase ATP synthase subunit beta, mitochondrial 3- phosphoinositide- dependent protein kinase 1 RAC-alpha serine/threonine- protein kinase Long-chain fatty acid transport protein 1 Mitochondrial carnitine/acylcarnitine carrier protein Solute carrier family 2, facilitated glucose transporter member 4 Mitochondrial pyruvate carrier 1 Solute carrier family 22 member 5 Long-chain- fatty-acid-- CoA ligase 1 Carnitine O- palmitoyltransferase 1, liver isoform Carnitine O- palmitoyltransferase 2, mitochondrial ATP synthase lipid-binding protein, mitochondrial ATP synthase subunit a ATP synthase subunit alpha, mitochondrial ATP synthase subunit b, mitochondrial ATP synthase subunit delta, mitochondrial ATP synthase subunit epsilon, mitochondrial ATP synthase subunit gamma, mitochondrial RAC-alpha serine/threonine- protein kinase Serine/threonine- protein phosphatase 2A catalytic subunit alpha isoform Carnitine O- acetyltransferase L- Palmitoylcarnitine L- Palmitoylcarnitine PIP3(16:0/16:0) Palmitoyl-CoA Acetyl-CoA Palmitoyl-CoA Palmitic acid D-Glucose Pyruvic acid NADH Superoxide Palmitic acid L- Palmitoylcarnitine D-Glucose Pyruvic acid Ca+ Ca+ Na+ Na+ K+ K+ L-Carnitine L-Carnitine ATP CoA AMP PPi CoA L-Carnitine CoA CoA NAD CO2 NADH ADP H+ ATP H+ L-Carnitine L- Acetylcarnitine CoA Na+ ATP K+ H2O Na+ ADP Pi K+ Pi Thiamine pyrophosphate Lipoamide FAD Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Activation of peroxisomal FA Ooxidation Glycolysis TCA Cycle Mitochondrial Electron Transport Chain Insulin Signalling AKT signaling pathway Pi Pi Magnesium Cytosol Mitochondrial Outer Membrane Mitochondrial Inter-membrane Space Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Space
Mitochondria Unknown INSR PDHA1 FXYD2 ATP2A2 FXYD2 ATP5B PDPK1 AKT1 SLC27A1 SLC25A20 SLC2A4 MPC1 SLC22A5 ACSL1 CPT1A CPT2 ATP5G2 MT-ATP6 ATP5A1 ATP5F1 ATP5D ATP5E ATP5C1 AKT1 PPP2CA CRAT L- Palmitoylcarnitine L- Palmitoylcarnitine PIP3(16:0/16:0) Palmitoyl-CoA Acetyl-CoA Palmitoyl-CoA Palmitic acid D-Glucose Pyruvic acid NADH Superoxide Palmitic acid L- Palmitoylcarnitine D-Glucose Pyruvic acid Calcium Calcium Sodium Sodium Potassium Potassium L-Carnitine L-Carnitine Adenosine triphosphate Coenzyme A Adenosine monophosphate Pyrophosphate Coenzyme A L-Carnitine Coenzyme A Coenzyme A NAD Carbon dioxide NADH Adenosine diphosphate Hydrogen Adenosine triphosphate Hydrogen L-Carnitine L- Acetylcarnitine Coenzyme A Sodium Adenosine triphosphate Potassium Water Sodium Adenosine diphosphate Phosphate Potassium Phosphate Mitochondrial Beta-Oxidation of Long Chain Saturated Fatty Acids Activation of peroxisomal FA Ooxidation Glycolysis TCA Cycle Mitochondrial Electron Transport Chain Insulin Signalling AKT signaling pathway Phosphate Phosphate
INSR PDHA1 FXYD2 ATP2A2 FXYD2 ATP5B PDPK1 AKT1 SLC27A1 SLC25A20 SLC2A4 MPC1 SLC22A5 ACSL1 CPT1A CPT2 ATP5G2 MT-ATP6 ATP5A1 ATP5F1 ATP5D ATP5E ATP5C1 AKT1 PPP2CA CRAT L-Plmtc L-Plmtc PIP316 COA16:0 Ac-CoA COA16:0 16:0 D-Glc Pyr NADH O2(-) 16:0 L-Plmtc D-Glc Pyr Ca+ Ca+ Na+ Na+ K+ K+ L-Carnt L-Carnt ATP CoA AMP PPi CoA L-Carnt CoA CoA NAD CO2 NADH ADP H+ ATP H+ L-Carnt L-Alcar CoA Na+ ATP K+ H2O Na+ ADP Pi K+ Pi ThiamPP Lipoamd FAD PW000173 A o p F PW000146 PW002364 PW000165 PW000454 PW109148 Pi Pi Mg2+ Cytosol Mitochondrial Outer Membrane Mitochondrial Inter-membrane Space Mitochondrial Inner Membrane Mitochondrial Matrix Extracellular Space
Mitochondria INSR PDHA1 FXYD2 ATP2A2 FXYD2 ATP5B PDPK1 AKT1 SLC27A1 SLC25A20 SLC2A4 MPC1 SLC22A5 ACSL1 CPT1A CPT2 ATP5G2 MT-ATP6 ATP5A1 ATP5F1 ATP5D ATP5E ATP5C1 AKT1 PPP2CA CRAT L-Plmtc L-Plmtc PIP316 COA16:0 Ac-CoA COA16:0 16:0 D-Glc Pyr NADH O2(-) 16:0 L-Plmtc D-Glc Pyr Ca2+ Ca2+ Na+ Na+ K+ K+ L-Carnt L-Carnt ATP CoA AMP Ppi CoA L-Carnt CoA CoA NAD CO2 NADH ADP H2 ATP H2 L-Carnt L-Alcar CoA Na+ ATP K+ H2O Na+ ADP Pi K+ Pi PW000173 A o p F PW000146 PW002364 PW000165 PW000454 PW109148 Pi Pi