Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
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Muscarinic acetylcholine receptor M2 Guanine nucleotide- binding protein G(i) subunit alpha-1 Adenylyl Cyclase Sodium/potassium ATPase cAMP-dependent protein kinase catalytic subunit alpha L type Calcium channel High affinity choline transporter 1 Vesicular acetylcholine transporter Choline O- acetyltransferase Acetylcholine cAMP Atropine Choline Choline Acetylcholine Acetylcholine Na+ Na+ K+ K+ Ca+ Ca+ Atropine Acetyl-CoA CoA ATP PPi ATP GTP Gi/o signalling Due to decreased signalling, adenylyl cyclase is less inhibited leading to increased produciton of cAMP. Magnesium Magnesium Synaptic Vesicle Increased cAMP production increases the amount of calcium influx into cardiomyocyte cells. Increased calcium influx and ATPase activity leads to more contraction of the muscle, leads to increased heart rate and AV node conduction. Atropine inhibits the binding of acetylcholine to the muscarinic receptor. Less receptor activation leads to decreased downstream signalling. Increased cAMP production increases action potential concentration movement promoting action potentials. Cardiomyocyte Cytosol Vagus Nerve Vagus nerves release acetylcholine onto SA/VA node cells that binds to muscarinic receptors (Specifically M2) Atropine is administered as an intravenous injection
CHRM2 GNAI1 ADCY9 FXYD2 PRKACA CACNA2D2 GNB1 GNG2 SLC5A7 SLC18A3 CHAT Acetylcholine cAMP Atropine Choline Choline Acetylcholine Acetylcholine Sodium Sodium Potassium Potassium Calcium Calcium Atropine Acetyl-CoA Coenzyme A Adenosine triphosphate Pyrophosphate Adenosine triphosphate Guanosine triphosphate Gi/o signalling