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Neutral amino
acid
transporter
B(0)
Neutral amino
acid
transporter
B(0)
Dihydroorotate
mitochondrial
transporter
Orotate
mitochondrial
transporter
Orotate
membrane
transporter
CAD protein
CAD protein
CAD protein
Dihydroorotate
dehydrogenase
(quinone),
mitochondrial
Orotate
L-Glutamine
L-Glutamine
L-Glutamine
Dihydroorotate
Dihydroorotate
Orotate
Orotate
L-Glutamine
L-Glutamine
ATP
H
2
O
HCO
3
-
Carbamoyl phosphate
ADP
P
i
L-Aspartic acid
N-Carbamoyl-L-aspartate
P
i
H
2
O
Quinone
Hydroquinone
Zinc (II) ion
Zinc (II) ion
Zinc (II) ion
Endothelial
dysfunction &
hypertension
Renal failure
Neurotoxicity
Flavin
Mononucleotide
Hepatic Cell
Intestinal Lumen
Intestinal epithelial cells
Intestinal epithelial cells
L-glutamine is obtain from
protein foods such as meat
and eggs
Cytosol
Mitochondria
Mitochondrial outer membrane
Mitochondrial inner membrane