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Pathway Description
Metabolism and Physiological Effects of Uridine
Homo sapiens
Metabolic Pathway
Created: 2021-10-20
Last Updated: 2023-10-25
Uridine, also known as beta-uridine or 1-beta-D-ribofuranosylpyrimidine-2,4(1H,3H)-dione, is a member of the class of compounds known as pyrimidine nucleosides. Pyrimidine nucleosides are compounds comprising a pyrimidine base attached to a ribosyl or deoxyribosyl moiety. More specifically, uridine is a nucleoside consisting of uracil and D-ribose and a component of RNA. L-glutamine is obtained form protein sources in the diet and is metabolized to uridine in the liver. L-glutamine is first converted to carbamoyl phosphate then to N-Carbamoyl-L-aspartate and finally to dihydroorotate by the CAD protein (carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase). Dihydroorotate is converted to orotate in the mitochondria of the cell using the enzyme dihydroorotate dehydrogenase .Orotate is converted to orotidine 5'-phosphate then Uridine 5'-monophosphate by the enzyme uridine 5'-monophosphate synthase. Finally, uridine 5'-monophosphate forms uridine via cytosolic 5'-nucleotidase 1B. uridine enters the blood stream and may have affect tissues such as the kidney, where it can contribute to renal failure.
References
Metabolism and Physiological Effects of Uridine References
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