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Neutral amino
acid
transporter
B(0)
Neutral amino
acid
transporter
B(0)
Dihydroorotate
mitochondrial
transporter
Orotate
mitochondrial
transporter
Sodium/nucleoside
cotransporter 1
CAD protein
CAD protein
CAD protein
Dihydroorotate
dehydrogenase
(quinone),
mitochondrial
Uridine 5'-
monophosphate
synthase
Uridine 5'-
monophosphate
synthase
Cytosolic
5'-nucleotidase
1B
Uridine
L-Glutamine
L-Glutamine
L-Glutamine
L-Glutamine
Dihydroorotate
Dihydroorotate
Orotate
Orotate
Uridine
ATP
H
2
O
HCO
3
-
Carbamoyl phosphate
ADP
P
i
L-Aspartic acid
N-Carbamoyl-L-aspartate
P
i
H
2
O
Quinone
Hydroquinone
5-Phospho-alpha-D-ribose
1-diphosphate
PP
i
Orotidine 5'-phosphate
Uridine 5'-monophosphate
CO
2
H
2
O
P
i
Zinc (II) ion
Zinc (II) ion
Zinc (II) ion
Kidney disease
Flavin
Mononucleotide
Magnesium
Hepatocyte
Intestinal Lumen
Intestinal Epithelial Cells
Intestinal Epithelial Cells
L-glutamine is obtain from
protein foods such as meat
and eggs
Cytosol
Mitochondria
Mitochondrial Outer Membrane
Mitochondrial Inner Membrane