Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
Loader

Loading Pathway...

Thyroid peroxidase Thyroglobulin Sodium/iodide cotransporter Pendrin Thyroglobulin Thyroid peroxidase Methimazole transporter Thyroid peroxidase Thyroid peroxidase Thyroid peroxidase Iodotyrosine deiodinase 1 Type I iodothyronine deiodinase Unknown Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Thyroglobulin Methimazole Iodotyrosine 3,5-Diiodo-L-tyrosine Thyroxine Liothyronine Iodide Iodide Na+ Na+ Iodide Thyroxine Liothyronine Methimazole H2O2 H+ Iodine H2O H2O2 H2O H2O2 H2O NADPH L-Tyrosine NADP Iodide NADPH L-Tyrosine NADP Iodide Carbimazole Calcium Heme Calcium Calcium Calcium FMN FMN Thyroxine Liothyronine Liothyronine Thyroxine Iodotyrosine 3,5-Diiodo-L-tyrosine 2-Aminoacrylic acid 2-Aminoacrylic acid Amino acids Thyroglobulin proteolysis Protein Synthesis Calcium Heme Heme Heme Heme Exocytosis Endocytosis Endocytosis Secretion Secretion Follicle lumen Follicle cell Plasma Cytosol Methimazole inhibits thyroid peroxidase, preventing the oxidation of iodide The incorporation of iodine into tyrosine molecules in thyroglobulin is also inhibited The production of T3 and T4 is decreased The concentration of T3 and T4 secreted from the thyroid follicle cell is decreased Carbimazole is converted into its active form, methimazole, which is transported into the thyroid follicle cell
TPO TG SLC5A5 SLC26A4 TG TPO Unknown TPO TPO TPO DIO1 DIO1 Unknown TG TG TG TG TG TG TG TG Methimazole Iodotyrosine 3,5-Diiodo-L- tyrosine Thyroxine Liothyronine Iodide Iodide Sodium Sodium Iodide Thyroxine Liothyronine Methimazole Hydrogen peroxide Hydrogen Ion Iodine Water Hydrogen peroxide Water Hydrogen peroxide Water NADPH L-Tyrosine NADP Iodide NADPH L-Tyrosine NADP Iodide Carbimazole Thyroxine Liothyronine Liothyronine Thyroxine Iodotyrosine 3,5-Diiodo-L- tyrosine 2-Aminoacrylic acid 2-Aminoacrylic acid Amino acids Thyroglobulin proteolysis Protein Synthesis