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Egl nine
homolog 2
hypoxia-
inducible
factor-1α
Succinate
receptor 1
Guanine
nucleotide-
binding protein
G(q) subunit
alpha
1-
phosphatidylinositol
4,5-
bisphosphate
phosphodiesterase
beta-1
Inositol 1,4,5-
trisphosphate
receptor type 1
Protein kinase
C alpha type
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Nitric oxide
synthase,
endothelial
Mitogen-
activated
protein kinase
1
Mitogen-
activated
protein kinase
3
Prostaglandin
G/H synthase 2
Prostaglandin
G/H synthase 1
Nuclear factor
NF-kappa-B p105
subunit
Toll-like
receptor 4
Ubiquitinated
hypoxia
inducible
factor 1 alpha
Solute carrier
family 2,
facilitated
glucose
transporter
member 2
Voltage-
dependent
anion-selective
channel protein
2
Pyruvate
carboxylase,
mitochondrial
Mitochondrial
dicarboxylate
carrier
Voltage-
dependent
anion-selective
channel protein
1
Succinate
nuclear
transporter
Hydroxylated
hypoxia-
inducible
factor 1-alpha
Hydroxylated
hypoxia-
inducible
factor 1-alpha
Nuclear pore
Solute carrier
family 13
member 3
citrate
synthase
Aconitate
hydratase,
mitochondrial
Aconitate
hydratase,
mitochondrial
Malate
dehydrogenase,
mitochondrial
Fumarate
hydratase,
mitochondrial
Pyruvate
dehydrogenase
E1 component
subunit alpha,
somatic form,
mitochondrial
Pyruvate
dehydrogenase
E1 component
subunit beta,
mitochondrial
Dihydrolipoyllysine-
residue
acetyltransferase
component of
pyruvate
dehydrogenase
complex,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
Succinyl-CoA
ligase
[ADP/GDP-
forming]
subunit alpha,
mitochondrial
Succinyl-CoA
ligase
[GDP-forming]
subunit beta,
mitochondrial
Probable
2-oxoglutarate
dehydrogenase
E1 component
DHKTD1,
mitochondrial
Dihydrolipoyllysine-
residue
succinyltransferase
component of
2-oxoglutarate
dehydrogenase
complex,
mitochondrial
Dihydrolipoyl
dehydrogenase,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
alpha,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
beta,
mitochondrial
Isocitrate
dehydrogenase
[NAD] subunit
gamma,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
flavoprotein
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
iron-sulfur
subunit,
mitochondrial
Succinate
dehydrogenase
cytochrome b560
subunit,
mitochondrial
Succinate
dehydrogenase
[ubiquinone]
cytochrome b
small subunit,
mitochondrial
Von
Hippel-Lindau
disease tumor
suppressor
Cytosolic
phospholipase
A2
Prostaglandin E
synthase
Succinic acid
Succinic acid
Inositol 1,4,5-
trisphosphate
Ca
+
Lipopolysaccharide
D-Glucose
pyruvate
NO
Prostaglandin
E2
D-Glucose
pyruvate
pyruvate
Succinic acid
Succinic acid
Succinic acid
Ca
+
Acetyl-CoA
H
2
O
Oxaloacetate
Citrate
CoA
cis-Aconitic
acid
H
2
O
H
2
O
Isocitric acid
Malate
NAD
NADH
H
+
Fumaric acid
H
2
O
CoA
NADP
CO
2
NADPH
ATP
CoA
Succinyl-CoA
ADP
P
i
Oxoglutaric
acid
NAD
CoA
NADH
H
+
CO
2
NAD
CO
2
NADH
H
+
Hydroquinone
Quinone
Phosphatidylinositol
4,5-
bisphosphate
Arachidonic
acid
Prostaglandin
H2
O
2
Prostaglandin
G2
H
2
O
H
+
L-Arginine
NADPH
O
2
H
2
O
L-Citrulline
NADP
Ascorbic acid
Calcium
Heme
Heme
Heme
Heme
Heme
Biotin
Manganese
4Fe-4S
4Fe-4S
Thiamine
pyrophosphate
Lipoamide
Magnesium
FAD
2Fe-2S
Calcium
Glutathione
Diacylglycerol
Reactive oxygen
species
Phospholipids
Acceptor
Reduced
acceptor
IL-1β
IL-1β
Glycolysis
Proteasomal
degradation
Inflammation
TLR4 receptor
signaling
pathway