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Reverse transcriptase protein Delavirdine transporter Delavirdine Delavirdine Viral Proteins Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex HIV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Delavirdine binds directly to reverse transcriptase (RT) and blocks the RNA-dependent and DNA-dependent DNA polymerase activities by causing a disruption of the enzyme's catalytic site. The activity of Delavirdine does not compete with template or nucleoside triphosphates. Viral DNA Viral mRNA Viral mRNA
Nucleus reverse transcriptase Unknown Delavirdine Delavirdine Viral Proteins NUP98 Unknown