Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Reverse transcriptase protein Solute carrier family 22 member 6 Zalcitabine nuclear transporter Zalcitabine monophosphate nuclear transporter Deoxycytidine kinase UMP-CMP kinase Nucleoside diphosphate kinase A Dideoxycytidine triphosphate Zalcitabine Zalcitabine Zalcitabine Dideoxycytidine monophosphate Dideoxycytidine monophosphate Dideoxycytidine diphosphate dCTP Magnesium Viral Proteins Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex Magnesium HIV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Dideoxycytidine triphosphate inhibits the activity of reverse transcriptase by competing with its substrate dCTP. Dideoxycytidine triphosphate also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Extracellular Space Viral mRNA Viral mRNA
Nucleus reverse transcriptase SLC22A6 Unknown Unknown DCK CMPK1 NME1 Dideoxycytidine triphosphate Zalcitabine Zalcitabine Zalcitabine Dideoxycytidine monophosphate Dideoxycytidine monophosphate Dideoxycytidine diphosphate dCTP Viral Proteins NUP98 Unknown