Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Reverse transcriptase Adefovir monophosphate outer mitochondrial transporter Adefovir monophosphate inner mitochondrial transporter Adefovir inner mitochondrial transporter Adefovir outer mitochondrial transporter Solute carrier family 22 member 6 Liver carboxylesterase 1 Adefovir Diphosphate Adefovir Monophosphate Adefovir Monophosphate Adefovir Monophosphate Adefovir Adefovir Adefovir Adefovir Dipivoxil Adefovir Dipivoxil Deoxyadenosine triphosphate Nucleoside diphosphate kinase A Nucleoside diphosphate kinase B Viral Proteins Adenylate kinase 2, mitochondrial Adenylate kinase 4, mitochondrial Magnesium Magnesium Nuclear pore complex protein Nup98-Nup96 Nuclear pore complex HIV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Adefovir diphosphate also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Extracellular Space Adefovir diphosphate inhibits the activity of reverse transcriptase by competing with its substrate dATP. Mitochondria Outer membrane Inner membrane Viral DNA Viral mRNA Viral mRNA
Nucleus Mitochondria P Unknown Unknown Unknown Unknown SLC22A6 CES1 Adefovir Diphosphate Adefovir Monophosphate Adefovir Monophosphate Adefovir Monophosphate Adefovir Adefovir Adefovir Adefovir Dipivoxil Adefovir Dipivoxil Deoxyadenosine triphosphate NME1 NME2 Viral Proteins AK2 AK4 NUP98 Unknown