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Flurouracil Transport Floxuridine Nuclear Transporter 5- Fluorodeoxyuridine Monophosphate Nuclear Transporter Capecitabine transporter Thymidylate synthase Thymidylate synthase Soluble calcium- activated nucleotidase 1 Nucleoside diphosphate kinase 6 Soluble calcium- activated nucleotidase 1 Uridine 5'- monophosphate synthase UMP-CMP kinase Nucleoside diphosphate kinase 6 Thymidine phosphorylase Ribonucleoside- diphosphate reductase large subunit Ribonucleoside- diphosphate reductase subunit M2 Nucleoside diphosphate kinase 6 Thymidine kinase, cytosolic Thymidine phosphorylase Thymidylate synthase Thymidine 5'-triphosphate 5-Fluorodeoxyuridine triphosphate Fluorouracil Fluorouracil Floxuridine Floxuridine 5-Fluorodeoxyuridine monophosphate 5-Fluorodeoxyuridine monophosphate Capecitabine Capecitabine dUMP 5,10-Methylene-THF 5-Thymidylic acid Dihydrofolic acid ATP dTDP ADP H2O Pi ATP ADP H2O Pi Phosphoribosyl pyrophosphate 5-Fluorouridine monophosphate PPi ATP ADP 5-Fluorouridine diphosphate ATP ADP 5-Fluorouridine triphosphate Deoxyribose 1-phosphate Pi H2O 5-Fluorodeoxyuridine diphosphate ATP ADP ATP ADP Uridine triphosphate Fe3+ 5-Fluorodeoxyuridine monophosphate 5,10-Methylene-THF Thioredoxin Thioredoxin disulfide DNA Synthesis DNA Synthesis Calcium Magnesium Calcium Magnesium Magnesium Magnesium Fraudulent RNA 5-Fluorodeoxyuridine monophosphate forms a complex with thymidylate synthase and 5, 10-Methylene-THF. This prevents the conversion of dUMP to 5-Thymidylic acid (dTMP) which is further converted to dTTP, an important precursor for DNA synthesis. DNA synthesis cannot occur as thymidine 5'-triphosphate isn't being produced. This causes the cell to die as it cannot undergo replication, proliferation or differentiation. Fluorouracil is converted to 5-Fluorouridine triphosphate through a series of phosphorylation steps. 5-Fluorouridine triphosphate is incorporated into RNA in place of uracil creating fraudulent RNA that cannot synthesize the correct proteins. Nucleus Cytosol Extracellular Space 5-Fluorouridine triphosphate prevents uridine triphosphate (UTP) from being incorporated in RNA. Fluorouracil is also converted into 5-fluorodeoxyuridine triphosphate through phosphorylation and reduction. 5-Fluorodeoxyuridine triphosphate can be incorporated into DNA synthesis and replication creating fraudulent DNA. This causes the cell to die as it cannot synthesize DNA peroperly.
Nucleus Unknown Unknown Unknown Unknown TYMS TYMS CANT1 NME6 CANT1 UMPS CMPK1 NME6 TYMP RRM1 RRM2 NME6 TK1 TYMP TYMS Thymidine 5'-triphosphate 5- Fluorodeoxyuridine triphosphate Fluorouracil Fluorouracil Floxuridine Floxuridine 5- Fluorodeoxyuridine monophosphate 5- Fluorodeoxyuridine monophosphate Capecitabine Capecitabine dUMP 5,10- Methylene-THF 5-Thymidylic acid Dihydrofolic acid Adenosine triphosphate dTDP Adenosine diphosphate Water Phosphate Adenosine triphosphate Adenosine diphosphate Water Phosphate Phosphoribosyl pyrophosphate 5-Fluorouridine monophosphate Pyrophosphate Adenosine triphosphate Adenosine diphosphate 5-Fluorouridine diphosphate Adenosine triphosphate Adenosine diphosphate 5-Fluorouridine triphosphate Deoxyribose 1-phosphate Phosphate Water 5- Fluorodeoxyuridine diphosphate Adenosine triphosphate Adenosine diphosphate Adenosine triphosphate Adenosine diphosphate Uridine triphosphate 5- Fluorodeoxyuridine monophosphate 5,10- Methylene-THF Thioredoxin Thioredoxin disulfide DNA Synthesis DNA Synthesis
TYMS TYMS CANT1 NME6 CANT1 UMPS CMPK1 NME6 TYMP RRM1 RRM2 NME6 TK1 TYMP TYMS Tm5TP 5FT FloUrl FloUrl Fdu Fdu 5FM 5FM Capec Capec dUMP 5XM-THF 5TMA FAH2 ATP dTDP ADP H2O Pi ATP ADP H2O Pi PRPP 5FM PPi ATP ADP 5FD ATP ADP 5FT D1P Pi H2O 5FD ATP ADP ATP ADP UTP Fe3+ 5FM 5XM-THF Thiored TD DNA Syn DNA Syn Ca2+ Mg2+ Ca2+ Mg2+ Mg2+ Mg2+ Fraudulent RNA 5-Fluorodeoxyuridine monophosphate forms a complex with thymidylate synthase and 5, 10-Methylene-THF. This prevents the conversion of dUMP to 5-Thymidylic acid (dTMP) which is further converted to dTTP, an important precursor for DNA synthesis. DNA synthesis cannot occur as thymidine 5'-triphosphate isn't being produced. This causes the cell to die as it cannot undergo replication, proliferation or differentiation. Fluorouracil is converted to 5-Fluorouridine triphosphate through a series of phosphorylation steps. 5-Fluorouridine triphosphate is incorporated into RNA in place of uracil creating fraudulent RNA that cannot synthesize the correct proteins. Nucleus Cytosol Extracellular Space 5-Fluorouridine triphosphate prevents uridine triphosphate (UTP) from being incorporated in RNA. Fluorouracil is also converted into 5-fluorodeoxyuridine triphosphate through phosphorylation and reduction. 5-Fluorodeoxyuridine triphosphate can be incorporated into DNA synthesis and replication creating fraudulent DNA. This causes the cell to die as it cannot synthesize DNA peroperly.
Nucleus TYMS TYMS CANT1 NME6 CANT1 UMPS CMPK1 NME6 TYMP RRM1 RRM2 NME6 TK1 TYMP TYMS Tm5TP 5FT FloUrl FloUrl Fdu Fdu 5FM 5FM Capec Capec dUMP 5XM-THF 5TMA FAH2 ATP dTDP ADP H2O Pi ATP ADP H2O Pi PRPP 5FM Ppi ATP ADP 5FD ATP ADP 5FT D1P Pi H2O 5FD ATP ADP ATP ADP UTP 5FM 5XM-THF Thiored TD DNA Syn DNA Syn