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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Lorazepam L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Lorazepam Lorazepam Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA A receptor in between the alpha and beta subunits. This causes the chloride channel to open causing hyper-polarization in the post synaptic neuron suppressing signalling. Lorazepam binds to an allosteric site of the GABA A receptor between the gamma and alpha subunits. This also causes the chloride channel to open more frequently causing hyper-polarization in the post synaptic neuron further suppressing signalling. Cytosol Cytosol Synapse Lorazepam is administered as an oral tablet
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Lorazepam L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Lorazepam Lorazepam Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Ativan Glu Cl- GABA Ca+ Ativan Ativan Cl- CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Hyper Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA A receptor in between the alpha and beta subunits. This causes the chloride channel to open causing hyper-polarization in the post synaptic neuron suppressing signalling. Lorazepam binds to an allosteric site of the GABA A receptor between the gamma and alpha subunits. This also causes the chloride channel to open more frequently causing hyper-polarization in the post synaptic neuron further suppressing signalling. Cytosol Cytosol Synapse Lorazepam is administered as an oral tablet
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca2+ Ativan Glu Cl GABA Ca2+ Ativan Ativan Cl CO2 ATP Ppi Gi/ sig PW000003 Hyper