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Pathway Description
Azithromycin Action Pathway (New)
Homo sapiens
Drug Action Pathway
Created: 2022-01-19
Last Updated: 2023-10-25
Azithromycin is a macrolide antibiotic used to treat a variety of bacterial infections.
It is a broad-spectrum macrolide antibiotic with a long half-life and a high degree of tissue penetration. It is primarily used for the treatment of respiratory, enteric and genitourinary infections and may be used instead of other macrolides for some sexually transmitted and enteric infections. Like other macrolide antimicrobials, azithromycin binds to the 23S portion of the 50S bacterial ribosomal subunit. It inhibits bacterial protein synthesis by preventing the transit of aminoacyl-tRNA and the growing protein through the ribosome. Inhibition of protein synthesis kills the bacteria since essential proteins required for the bacteria to survive are not being produced.
References
Azithromycin Pathway (New) References
Sandman Z, Iqbal OA: Azithromycin
Pubmed: 32491698
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Ng LK, Martin I, Liu G, Bryden L: Mutation in 23S rRNA associated with macrolide resistance in Neisseria gonorrhoeae. Antimicrob Agents Chemother. 2002 Sep;46(9):3020-5. doi: 10.1128/AAC.46.9.3020-3025.2002.
Pubmed: 12183262
Jalava J, Vaara M, Huovinen P: Mutation at the position 2058 of the 23S rRNA as a cause of macrolide resistance in Streptococcus pyogenes. Ann Clin Microbiol Antimicrob. 2004 May 6;3:5. doi: 10.1186/1476-0711-3-5.
Pubmed: 15128458
Pereyre S, Renaudin H, Charron A, Bebear C, Bebear CM: Emergence of a 23S rRNA mutation in Mycoplasma hominis associated with a loss of the intrinsic resistance to erythromycin and azithromycin. J Antimicrob Chemother. 2006 Apr;57(4):753-6. doi: 10.1093/jac/dkl026. Epub 2006 Feb 7.
Pubmed: 16464889
Marvig RL, Sondergaard MS, Damkiaer S, Hoiby N, Johansen HK, Molin S, Jelsbak L: Mutations in 23S rRNA confer resistance against azithromycin in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2012 Aug;56(8):4519-21. doi: 10.1128/AAC.00630-12. Epub 2012 May 29.
Pubmed: 22644032
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