Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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DNA polymerase DNA polymerase catalytic subunit Acyclovir transporter Thymidine kinase, cytosolic Guanylate kinase Nucleoside diphosphate kinase A Acyclovir triphosphate Aciclovir Aciclovir dGTP Pi Acyclovir monophosphate Pi Acyclovir diphosphate Pi Magnesium Viral Proteins HHV Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Acyclovir triphosphate also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Extracellular Space Acyclovir triphosphate inhibits the activity of DNA polymerase by competing with its substrate dGTP. Viral DNA Viral mRNA Viral mRNA
Nucleus UL30 ORF28 Unknown TK1 GUK1 NME1 Acyclovir triphosphate Aciclovir Aciclovir dGTP Phosphate Acyclovir monophosphate Phosphate Acyclovir diphosphate Phosphate Viral Proteins