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Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit zeta-1 Glutamate [NMDA] receptor subunit epsilon-3 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit epsilon-4 Glutamate receptor 1 Glutamate receptor 2 Voltage- dependent calcium channel subunit alpha-2/delta-1 Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent L-type calcium channel subunit alpha-1C Vesicular glutamate transporter 1 Excitatory amino acid transporter 2 Glutaminase kidney isoform, mitochondrial Glutamate [NMDA] receptor subunit 3B Glutamate [NMDA] receptor subunit 3A L-Glutamic acid Ca+ L-Glutamic acid Pregabalin Ca+ Na+ L-Glutamic acid Ca+ Na+ Ca+ L-Glutamine H2O Ammonium Depolarization Presynaptic neuron Post-synaptic neuron 2. An action potential arrives at the nerve terminal and stimulates the opening of the calcium channel, causing an influx of calcium ions 1. Glutamate is synthesized from glutamine and stored in synaptic vesicles at the nerve terminal 3. Calcium ions stimulates the release of neurotransmitter dopamine into the synaptic cleft via exocytosis 4. Glutamate in the synaptic cleft activates NMDA and AMPA receptors on the post synaptic membrane 5. Glutamate is taken back up into the presynaptic neuron and recycled 6. NMDA and AMPA receptor activation leads to influx of positive ions in the post synaptic cell causing depolarization/ excitation. With less synaptic glutamate, less receptors are activated and the influx of cations is not enough for depolarization to occur 7. Pregabalin inhibits the calcium channel, lowering intracellular calcium and synaptic glutamate and preventing depolarization of post synaptic neurons
GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIA1 GRIA2 CACNA2D1 CACNB1 CACNA1C SLC17A7 SLC1A2 GLS GRIN3B GRIN3A L-Glutamic acid Calcium L-Glutamic acid Pregabalin Calcium Sodium L-Glutamic acid Calcium Sodium Calcium L-Glutamine Water Ammonium Depolarization
GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIA1 GRIA2 CACNA2D1 CACNB1 CACNA1C SLC17A7 SLC1A2 GLS GRIN3B GRIN3A Glu Ca+ Glu Lyrica Ca+ Na+ Glu Ca+ Na+ Ca+ Gln H2O Ammon Depol Presynaptic neuron Post-synaptic neuron 2. An action potential arrives at the nerve terminal and stimulates the opening of the calcium channel, causing an influx of calcium ions 1. Glutamate is synthesized from glutamine and stored in synaptic vesicles at the nerve terminal 3. Calcium ions stimulates the release of neurotransmitter dopamine into the synaptic cleft via exocytosis 4. Glutamate in the synaptic cleft activates NMDA and AMPA receptors on the post synaptic membrane 5. Glutamate is taken back up into the presynaptic neuron and recycled 6. NMDA and AMPA receptor activation leads to influx of positive ions in the post synaptic cell causing depolarization/ excitation. With less synaptic glutamate, less receptors are activated and the influx of cations is not enough for depolarization to occur 7. Pregabalin inhibits the calcium channel, lowering intracellular calcium and synaptic glutamate and preventing depolarization of post synaptic neurons
GRIN2A GRIN1 GRIN2C GRIN2B GRIN2D GRIA1 GRIA2 CACNA2D1 CACNB1 CACNA1C SLC17A7 SLC1A2 GLS GRIN3B GRIN3A Glu Ca2+ Glu Lyrica Ca2+ Na+ Glu Ca2+ Na+ Ca2+ Gln H2O Ammon Depol