Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.

Loading Pathway...

Sodium- dependent noradrenaline transporter Alpha-1A adrenergic receptor Beta-1 adrenergic receptor Beta-2 adrenergic receptor Synaptic vesicular amine transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Aromatic-L- amino-acid decarboxylase Dopamine beta- hydroxylase Tyrosine 3-monooxygenase Ca+ Norepinephrine Amitriptyline Norepinephrine Norepinephrine Ca+ Amitriptyline Amitriptyline L-Dopa Dopamine CO2 Ascorbic acid O2 Dehydroascorbic acid H2O L-Tyrosine Tetrahydrobiopterin O2 Dihydrobiopterin H2O Pyridoxal 5'-phosphate Pyrroloquinoline quinone Copper Fe2+ Gq signaling cascade Gs signaling cascade Cytosol Postsynaptic Neuron Presynaptic Neuron Cytosol Synaptic Vesicle Synapse Norepinephrine is synthesized and stored in synaptic vesicles at the nerve terminal Amitriptyline inhibits the norepinephrine reuptake transporter, thereby increasing synaptic norepinephrine levels Mood Improvement Norepinephrine activates post synaptic adrenergic receptors which are responsible for mood improvements Blood-Brain Barrier Diffusion
SLC6A2 ADRA1A ADRB1 ADRB2 SLC18A2 CACNA1A CACNB1 CACNA2D2 DDC DBH TH Calcium Norepinephrine Amitriptyline Norepinephrine Norepinephrine Calcium Amitriptyline Amitriptyline L-Dopa Dopamine Carbon dioxide Ascorbic acid Oxygen Dehydroascorbic acid Water L-Tyrosine Tetrahydrobiopterin Oxygen Dihydrobiopterin Water Gq signaling cascade Gs signaling cascade