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Gq protein signaling cascade Phospholipase C Inositol 1,4,5- trisphosphate receptor type 1 Protein kinase C alpha type Voltage- dependent P/Q-type calcium channel subunit alpha-1A Voltage- dependent L-type calcium channel subunit beta-1 Voltage- dependent calcium channel subunit alpha-2/delta-2 Myosin light chain kinase, smooth muscle Muscarinic acetylcholine receptor M3 Myosin LC-P Myosin light chain 3 Calmodulin-1 Myosin light chain phosphatase Calmodulin-1 Inositol 1,4,5-trisphosphate Oxybutynin Ca+ Ca+ Ca+ Oxybutynin Phosphatidylinositol 4,5-bisphosphate Calcium Ca+ Diacylglycerol Muscle Contraction Muscle Relaxation Magnesium Calcium Manganese Sarcoplasmic Reticulum Myosin unbinds from actin causing muscle relaxation Decreased calcium is unable to bind readily to calmodulin so it does not activate myosin light chain kinase Activation of myosin light chain kinase leading to high concentration of myosin LC-P There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol Smooth Muscle Myocyte Oxybutynin is an antagonist of the Muscarinic acetylcholine receptor M3, as well as Muscarinic acetylcholine receptors M2 and M1 Actin Myosin Oxybutynin is administered as an oral tablet
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 MYLK CHRM3 MYL3 MYL3 CALM1 PPP1CB CALM1 Inositol 1,4,5- trisphosphate Oxybutynin Calcium Calcium Calcium Oxybutynin Phosphatidylinositol 4,5- bisphosphate Calcium Diacylglycerol Muscle Contraction Muscle Relaxation
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2 MYLK CHRM3 MYL3 MYL3 CALM1 PPP1CB CALM1 Inotp Oxybuty Ca+ Ca+ Ca+ Oxybuty P45P Ca2+ Ca+ Diacylg Mus Con Mus Rel Mg2+ Ca2+ Mn2+ Sarcoplasmic Reticulum Myosin unbinds from actin causing muscle relaxation Decreased calcium is unable to bind readily to calmodulin so it does not activate myosin light chain kinase Activation of myosin light chain kinase leading to high concentration of myosin LC-P There is an overall decrease in calcium levels in the cytosol caused by the inhibition of the Gq signaling cascade Cytosol Smooth Muscle Myocyte Oxybutynin is an antagonist of the Muscarinic acetylcholine receptor M3, as well as Muscarinic acetylcholine receptors M2 and M1 Actin Myosin Oxybutynin is administered as an oral tablet
GNAQ PLCB1 ITPR1 PRKCA CACNA1A CACNB1 CACNA2D2