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Retinoic acid
receptor
RXR-alpha
Apolipoprotein
A-V
Lipoprotein
lipase
Apolipoprotein
C-III
Peroxisome
proliferator-
activated
receptor alpha
Acyl-coenzyme A
synthetase
ACSM2A,
mitochondrial
Long-chain
fatty acid
transport
protein 1
Acetyl-CoA
carboxylase 1
Apolipoprotein
A-I
Apolipoprotein
A-II
Apolipoprotein
A-I
Apolipoprotein
A-II
Apolipoprotein
B-100
Long-chain
fatty acid
transport
protein 1
Lipoprotein
lipase
Bezafibrate
transporter
Bezafibrate
nuclear
transporter
Retinoic acid
receptor
RXR-alpha
Bezafibrate
Bezafibrate
Bezafibrate
H
2
O
Magnesium
Fatty Acids
HDL
VLDL
Fatty Acids
Fatty Acids
Triglyceride
Fatty Acid
Diacylglycerol
Lipoprotein
lipase
Apolipoprotein
A1
Apolipoprotein
A2
Apolipoprotein
C3
Apolipoprotein
B-100
Apolipoprotein
A5
Acyl-coenzyme A
synthetase
Fatty acid
transport
protein 1
Acetyl-CoA
carboxylase
Transcription/Translation
Fatty Acid
Biosynthesis
Transcription/Translation
HDL Synthesis
Transcription/Translation
Transcription/Translation
vLDL Synthesis
Fatty acid
metabolism
Peroxisome
proliferator-
activated
receptor alpha
Biotin
Manganese
Nucleus
Cytosol
1. Bezafibrate activates the
PPAR alpha receptor in
nucleus. PPAR alpha combines
with the RXR alpha receptor.
This complex regulates gene
transcription and
translation
2. There is a decreased
expression of enzymes
involved in fatty acid
biosynthesis, leading to a
reduction in fatty acid
3. There is an increased
expression of fatty acid
transporters and metabolic
enzymes which remove fatty
acid from the blood and
breaks it down in the
mitochondria
4. There is an increased
expression of enzymes which
a part of HDL and are
essential to HDL synthesis,
thus increasing plasma
levels of HDL
5. There is decreased
expression of proteins that
form part of vLDL, thus
decreasing vLDL levels
6. There is upregulation of
enzymes involved in
lipolysis and downregulation
of enzymes which inhibit
triglyceride catabolism
Nucleus
RXRA
APOA5
LPL
APOC3
PPARA
ACSM2A
SLC27A1
ACACA
APOA1
APOA2
APOA1
APOA2
APOB
SLC27A1
LPL
Unknown
Unknown
RXRA
Bezafibrate
Bezafibrate
Bezafibrate
Water
Fatty Acids
HDL
VLDL
Fatty Acids
Fatty Acids
Triglyceride
Fatty Acid
Diacylglycerol
Lipoprotein lipase
Apolipoprotein
A1
Apolipoprotein
A2
Apolipoprotein C3
Apolipoprotein
B-100
Apolipoprotein A5
Acyl-
coenzyme A
synthetase
Fatty acid
transport
protein 1
Acetyl-CoA
carboxylase
Transcription/Translation
Fatty Acid
Biosynthesis
Transcription/Translation
HDL Synthesis
Transcription/Translation
Transcription/Translation
vLDL Synthesis
Fatty acid
metabolism
PPARA
RXRA
APOA5
LPL
APOC3
PPARA
ACSM2A
SLC27A1
ACACA
APOA1
APOA2
APOA1
APOA2
APOB
SLC27A1
LPL
RXRA
Cedur
Cedur
Cedur
H
2
O
Mg2+
FA
HDL
VLDL
FA
FA
TG
FA
Diacylg
Lip lip
Apol A1
Apo A2
Apol C3
Ap B-10
Apol A5
A-c A s
F a t
Ac-Co c
PW000455
PW000167
PW000455
HDL Syn
PW000455
PW000455
vLD Syn
Fa ac m
PPARA
Biotin
Mn2+
Nucleus
Cytosol
1. Bezafibrate activates the
PPAR alpha receptor in
nucleus. PPAR alpha combines
with the RXR alpha receptor.
This complex regulates gene
transcription and
translation
2. There is a decreased
expression of enzymes
involved in fatty acid
biosynthesis, leading to a
reduction in fatty acid
3. There is an increased
expression of fatty acid
transporters and metabolic
enzymes which remove fatty
acid from the blood and
breaks it down in the
mitochondria
4. There is an increased
expression of enzymes which
a part of HDL and are
essential to HDL synthesis,
thus increasing plasma
levels of HDL
5. There is decreased
expression of proteins that
form part of vLDL, thus
decreasing vLDL levels
6. There is upregulation of
enzymes involved in
lipolysis and downregulation
of enzymes which inhibit
triglyceride catabolism