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Fenofibryl Glucuronide membrane transporter Fenofibric acid membrane transporter Reduced Fenofibric Acid Glucuronide membrane transporter Fenofibrate transporter Fenofibrate intestinal transporter Liver carboxylesterase 1 Carbonyl reductase [NADPH] 1 UDP- glucuronosyltransferase 1-9 UDP- glucuronosyltransferase 1-9 Fenofibric acid Fenofibryl Glucuronide Reduced Fenofibric Acid Glucuronide Fenofibrate Fenofibrate Fenofibryl Glucuronide Fenofibryl Glucuronide Fenofibric acid Reduced Fenofibric Acid Glucuronide Reduced Fenofibric Acid Glucuronide Fenofibrate Fenofibrate Fenofibrate H2O H+ Isopropyl alcohol H+ NADPH Fenirofibrate NADP Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate Uridine diphosphate glucuronic acid H+ Uridine 5'-diphosphate Excretion 70-75% of the dose recovered in the urine is in the form of fenofibryl glucuronide and 16% as fenofibric acid. 5-25% of a dose of fenofibrate is eliminated in the feces, while 60-88% is eliminated in the urine.
Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CES1 CBR1 UGT1A9 UGT1A9 Fenofibric acid Fenofibryl Glucuronide Reduced Fenofibric Acid Glucuronide Fenofibrate Fenofibrate Fenofibryl Glucuronide Fenofibryl Glucuronide Fenofibric acid Reduced Fenofibric Acid Glucuronide Reduced Fenofibric Acid Glucuronide Fenofibrate Fenofibrate Fenofibrate Water Hydrogen Ion Isopropyl alcohol Hydrogen Ion NADPH Fenirofibrate NADP Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Uridine diphosphate glucuronic acid Hydrogen Ion Uridine 5'-diphosphate Excretion
CES1 CBR1 UGT1A9 UGT1A9 Fen aci Fen Gl R F A Fnf Fnf Fen Gl Fen Gl Fen aci R F A R F A Fnf Fnf