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Unknown transport protein Unknown transport protein Unknown transport protein Unknown transport protein Unknown transport protein Unknown transport protein Unknown transport protein Unknown transport protein Cytochrome P450 2B6 Cytochrome P450 3A4 Cytochrome P450 2E1 Cytochrome P450 2B6 Corticosteroid 11-beta- dehydrogenase isozyme 1 Carbonyl reductase [NADPH] 1 (2R)-2-(tert-butylamino)-1- (3-chloro-5- hydroxyphenyl)propan-1-one (2R)-1-(3-chlorophenyl)-2- [(1-hydroxy-2-methylpropan- 2-yl)amino]propan-1-one Threohydrobupropion Erythrohydrobupropion Hydroxybupropion (2R)-2-(tert-butylamino)-1- (3-chlorophenyl)-3- hydroxypropan-1-one Bupropion Bupropion Bupropion Bupropion (2R)-2-(tert-butylamino)-1- (3-chlorophenyl)-3- hydroxypropan-1-one Erythrohydrobupropion Hydroxybupropion Threohydrobupropion (2R)-1-(3-chlorophenyl)-2- [(1-hydroxy-2-methylpropan- 2-yl)amino]propan-1-one (2R)-2-(tert-butylamino)-1- (3-chloro-5- hydroxyphenyl)propan-1-one NADP NADPH H+ Heme Heme Heme Renal and Fecal Excretion Intestine Heme 87% of the dose is excreted as metabolites renally and 10% is excreted fecally. Only 0.5% is excreted as bupropion. Hydroxybupropion, Threohydrobupropion, and Erythrohydrobuproprion are all active metabolites of bupropion. Bupropion is taken orally All transports for Bupropion and its metabolites are unknown. None of the major hepatic transporters transport bupropion. Intestinal Epithelial Cell Blood Vessel Hepatocyte Endoplasmic Reticulum Kidney Intestines Bile Ducts