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Methyldopa intestinal transporter Methyldopa membrane transporter 3,4- Dihydroxyphenylacetone glucuronide transporter Methyldopa membrane transporter Alpha- methyldopa- mono-O- sulfate transporter 3,4- Dihydroxyphenylacetone transporter Alpha- methyldopamine transporter Alpha- methylnorepinephrine transporter Alpha- methylepinephrine transporter 3-O-methyl- alpha- methyldopa sulfate transporter 3-O-methyl- alpha- methyldopa transporter 3-O-methyl- alpha- methyldopamine transporter Catechol O- methyltransferase Sulfotransferase 1A1 Aromatic-L- amino-acid decarboxylase Catechol O- methyltransferase Dopamine beta- hydroxylase Phenylethanolamine N- methyltransferase Unknown UDP- glucuronosyltransferase 1-1 Sulfotransferase 1A1 3,4- Dihydroxyphenylacetone glucuronide 3,4- Dihydroxyphenylacetone Alpha- methyldopamine Alpha- methylnorepinephrine Methyldopa Alpha- methyldopa- mono-O- sulfate Alpha- methylepinephrine 3-O-methyl- alpha- methyldopa 3-O-methyl- alpha- methyldopamine 3-O-methyl- alpha- methyldopa sulfate Methyldopa Methyldopa Methyldopa Methyldopa Methyldopa 3,4- Dihydroxyphenylacetone glucuronide Methyldopa Alpha- methyldopa- mono-O- sulfate 3,4- Dihydroxyphenylacetone Alpha- methyldopamine Alpha- methylnorepinephrine Alpha- methylepinephrine 3-O-methyl- alpha- methyldopa sulfate 3-O-methyl- alpha- methyldopa 3-O-methyl- alpha- methyldopamine S- Adenosylmethionine H+ S- Adenosylhomocysteine Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate H+ H+ CO2 S- Adenosylmethionine S- Adenosylhomocysteine H+ O2 Ascorbic acid H2O monodehydroascorbate radical S- Adenosylmethionine H+ S- Adenosylhomocysteine Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate H+ Pyridoxal 5'-phosphate Copper Excretion Magnesium Magnesium Methyldopa is taken orally or via injection Methyldopa and its metabolites are excreted in urine
Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown COMT SULT1A1 DDC COMT DBH PNMT Unknown UGT1A1 SULT1A1 3,4- Dihydroxyphenylacetone glucuronide 3,4- Dihydroxyphenylacetone Alpha- methyldopamine Alpha- methylnorepinephrine Methyldopa Alpha- methyldopa- mono-O- sulfate Alpha- methylepinephrine 3-O-methyl- alpha- methyldopa 3-O-methyl- alpha- methyldopamine 3-O-methyl- alpha- methyldopa sulfate Methyldopa Methyldopa Methyldopa Methyldopa Methyldopa 3,4- Dihydroxyphenylacetone glucuronide Methyldopa Alpha- methyldopa- mono-O- sulfate 3,4- Dihydroxyphenylacetone Alpha- methyldopamine Alpha- methylnorepinephrine Alpha- methylepinephrine 3-O-methyl- alpha- methyldopa sulfate 3-O-methyl- alpha- methyldopa 3-O-methyl- alpha- methyldopamine S- Adenosylmethionine Hydrogen Ion S- Adenosylhomocysteine Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate Hydrogen Ion Hydrogen Ion Carbon dioxide S- Adenosylmethionine S- Adenosylhomocysteine Hydrogen Ion Oxygen Ascorbic acid Water monodehydroascorbate radical S- Adenosylmethionine Hydrogen Ion S- Adenosylhomocysteine Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Phosphoadenosine phosphosulfate Adenosine 3',5'- diphosphate Hydrogen Ion Excretion
COMT SULT1A1 DDC COMT DBH PNMT UGT1A1 SULT1A1 3,-Di g 34D Alp-met Alp-met Amd A-m-m-O Alp-met 3-O-m- 3-O-m- 3-O-m-a Amd Amd Amd Amd Amd 3,-Di g Amd A-m-m-O 34D Alp-met Alp-met Alp-met 3-O-m-a 3-O-m- 3-O-m- SAMe H+ SAH Paps A3'5'PP H+ H+ CO2 SAMe SAH H+ O2 VitC H2O Monorad SAMe H+ SAH UDPGlcA UDP H+ Paps A3'5'PP H+ Pyr-5'P Cu Excre Mg2+ Mg2+ Methyldopa is taken orally or via injection Methyldopa and its metabolites are excreted in urine
COMT SULT1A1 DDC COMT DBH PNMT UGT1A1 SULT1A1 3,-Di g 34D Alp-met Alp-met Amd A-m-m-O Alp-met 3-O-m- 3-O-m- 3-O-m-a Amd Amd Amd Amd Amd 3,-Di g Amd A-m-m-O 34D Alp-met Alp-met Alp-met 3-O-m-a 3-O-m- 3-O-m- SAMe H+ SAH Paps A3'5'PP H+ H+ CO2 SAMe SAH H+ O2 VitC H2O Monorad SAMe H+ SAH UDPGlcA UDP H+ Paps A3'5'PP H+ Excre