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Rilpivirine intestinal transporter Rilpivirine glucuronide transporter Rilpivirine glucuronide transporter Solute carrier family 22 member 1 Canalicular multispecific organic anion transporter 2 Rilpivirine glucuronide transporter Hydroxylated rilpivirine metabolite transporter Hydroxylated rilpivirine metabolite transporter Hydroxylated rilpivirine metabolite transporter Hydroxylated rilpivirine metabolite transporter Cytochrome P450 3A4 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-4 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-1 Cytochrome P450 3A4 UDP- glucuronosyltransferase 1-1 Rilpivirine Hydroxylated rilpivirine metabolite (M1) Rilpivirine glucuronide (M6) Hydroxylated rilpivirine metabolite (M3) Hydroxylated rilpivirine metabolite (M2) Rilpivirine glucuronide (M7) Hydroxylated rilpivirine metabolite (M4) Rilpivirine glucuronide (M5) Rilpivirine Rilpivirine Rilpivirine Rilpivirine Rilpivirine glucuronide (M7) Rilpivirine glucuronide (M6) Rilpivirine Rilpivirine Rilpivirine glucuronide (M5) Hydroxylated rilpivirine metabolite (M2) Hydroxylated rilpivirine metabolite (M1) Hydroxylated rilpivirine metabolite (M3) Hydroxylated rilpivirine metabolite (M4) O2 FMNH2 Flavin Mononucleotide H2O H+ FMNH2 O2 H2O Flavin Mononucleotide H+ Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ FMNH2 O2 Flavin Mononucleotide H2O H+ Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ O2 FMNH2 Flavin Mononucleotide H+ H2O Uridine diphosphate glucuronic acid Uridine 5'-diphosphate H+ Heme Heme Heme Heme Excretion Cytosol Hepatocyte Endoplasmic Reticulum Intestinal Epithelial Cell
Endoplasmic Reticulum Unknown Unknown Unknown SLC22A1 ABCC3 Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 UGT1A4 CYP3A4 UGT1A1 CYP3A4 UGT1A1 Rilpivirine Hydroxylated rilpivirine metabolite (M1) Rilpivirine glucuronide (M6) Hydroxylated rilpivirine metabolite (M3) Hydroxylated rilpivirine metabolite (M2) Rilpivirine glucuronide (M7) Hydroxylated rilpivirine metabolite (M4) Rilpivirine glucuronide (M5) Rilpivirine Rilpivirine Rilpivirine Rilpivirine Rilpivirine glucuronide (M7) Rilpivirine glucuronide (M6) Rilpivirine Rilpivirine Rilpivirine glucuronide (M5) Hydroxylated rilpivirine metabolite (M2) Hydroxylated rilpivirine metabolite (M1) Hydroxylated rilpivirine metabolite (M3) Hydroxylated rilpivirine metabolite (M4) Oxygen FMNH2 Flavin Mononucleotide Water Hydrogen Ion FMNH2 Oxygen Water Flavin Mononucleotide Hydrogen Ion Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion FMNH2 Oxygen Flavin Mononucleotide Water Hydrogen Ion Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Oxygen FMNH2 Flavin Mononucleotide Hydrogen Ion Water Uridine diphosphate glucuronic acid Uridine 5'-diphosphate Hydrogen Ion Excretion