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Unknown
Unknown
GTP
cyclohydrolase
GTP
cyclohydrolase
GTP
cyclohydrolase
GTP
cyclohydrolase
6-pyruvoyl
tetrahydrobiopterin
synthase
Sepiapterin
reductase
Sepiapterin
reductase
Aldose
reductase
Carbonyl
reductase
[NADPH] 1
Sepiapterin
reductase
Carbonyl
reductase
[NADPH] 1
Sepiapterin
reductase
Dihydrofolate
reductase
Sepiapterin
reductase
Dihydropteridine
reductase
Tyrosine
3-monooxygenase
Aromatic-L-
amino-acid
decarboxylase
Tryptophan
5-hydroxylase 1
Aromatic-L-
amino-acid
decarboxylase
Guanosine triphosphate
Formamidopyrimidine nucleoside
triphosphate
H
2
O
2,5-Diaminopyrimidine
nucleoside triphosphate
Formic acid
H
2
O
Formic acid
2,5-Diamino-6-(5'-
triphosphoryl-3',4'-
trihydroxy-2'-oxopentyl)-
amino-4-oxopyrimidine
Dihydroneopterin triphosphate
H
2
O
Dyspropterin
PPPi
NADP
NADPH
1-hydroxy-2-Oxopropyl
tetrahydropterin
NADP
6-Lactoyltetrahydropterin
NADPH
NADP
NADPH
Sepiapterin
NADPH
7,8-Dihydroneopterin
NADP
NADP
NADPH
NADP
Tetrahydrobiopterin
NADPH
NADPH
NADP
H
2
O
Neopterin
NAD
NADH
Dihydrobiopterin
NADPH
NADP
O
2
L-Dopa
H
2
O
CO
2
L-Tryptophan
O
2
4a-Hydroxytetrahydrobiopterin
CO
2
Zinc
Zinc
Zinc
Zinc
Zinc
Pyridoxal
5'-phosphate
Fe2+
Pyridoxal
5'-phosphate
L-Tyrosine
Dopamine
5-Hydroxy-L-tryptophan
Serotonin
Purine
Metabolism
Fe2+
Cytosol
Clumsy or unusual gait, and
experiences involuntary
muscle contractions and
uncontrolled movements
(dystonia) due to low
dopamine and serotonin..