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Acetyl-CoA
acetyltransferase,
cytosolic
Hydroxymethylglutaryl-
CoA synthase,
mitochondrial
Mevalonate
kinase
Phosphomevalonate
kinase
Diphosphomevalonate
decarboxylase
Isopentenyl-
diphosphate
Delta-isomerase
1
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
Farnesyl
pyrophosphate
synthase
Geranylgeranyl
pyrophosphate
synthase
Squalene
synthase
Squalene
monooxygenase
Lanosterol
synthase
Delta(24)-
sterol
reductase
Lanosterol
14-alpha
demethylase
Delta(14)-
sterol
reductase
Delta(24)-
sterol
reductase
Methylsterol
monooxygenase 1
Sterol-4-
alpha-
carboxylate 3-
dehydrogenase,
decarboxylating
3-keto-steroid
reductase
3-beta-
hydroxysteroid-
Delta(8),Delta(7)-
isomerase
Delta(24)-
sterol
reductase
Delta(24)-
sterol
reductase
3-beta-
hydroxysteroid-
Delta(8),Delta(7)-
isomerase
3-beta-
hydroxysteroid-
Delta(8),Delta(7)-
isomerase
Lathosterol
oxidase
Delta(24)-
sterol
reductase
Delta(24)-
sterol
reductase
3-Hydroxy-3-
methylglutaryl-
coenzyme A
reductase
Sterol O-
acyltransferase
1
Lysosomal acid
lipase/cholesteryl
ester hydrolase
Acetoacetyl-CoA
Acetyl-CoA
Cholesterol
CoA
H
2
O
3-Hydroxy-3-methylglutaryl-CoA
CoA
Mevalonic acid
ATP
Mevalonic acid-5P
ADP
ATP
ADP
(R)-5-Diphosphomevalonic acid
ATP
ADP
P
i
Isopentenyl pyrophosphate
CO
2
Dimethylallylpyrophosphate
Geranyl-PP
PP
i
Farnesyl pyrophosphate
PP
i
NADPH
Squalene
NADP
PP
i
O
2
NADPH
(S)-2,3-Epoxysqualene
H
2
O
NADP
Lanosterol
NADPH
24,25-Dihydrolanosterol
NADP
O
2
NADPH
4,4-Dimethylcholesta-
8,14,24-trienol
Formic acid
NADP
H
2
O
NADPH
4,4-Dimethyl-5a-cholesta-
8,24-dien-3-b-ol
NADP
NADPH
4,4-Dimethyl-5a-cholesta-8-
en-3b-ol
NADP
NADPH
O
2
4a-Methylzymosterol-4-
carboxylic acid
NADP
H
2
O
NADP
3-Keto-4-methylzymosterol
NADPH
CO
2
NADPH
4a-Methylzymosterol
NADP
Zymosterol intermediate 2
5a-Cholesta-7,24-dien-3b-ol
NADPH
5a-Cholest-8-en-3b-ol
NADP
NADPH
Lathosterol
NADP
7-Dehydrodesmosterol
7-Dehydrocholesterol
NADPH
NADP
Desmosterol
NADPH
O
2
NADP
H
2
O
NADPH
NADP
NADPH
NADP
Vitamin D3
8-Dehydrocholesterol
NADPH
NADP
CoA
Fatty acid
Cholesterol Ester
H
2
O
Fatty acid
H
2
O
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
Magnesium
FAD
FAD
FAD
Iron
Butyrate
Metabolism
Pyruvate
Metabolism
Valine,
Leucine, and
Isoleucine
Degradation
Tryptophan
Metabolism
Pyruvate
Metabolism
Fatty Acid
Metabolism
Steroidogenesis
Bile Acid
Biosynthesis