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leucine--tRNA
ligase
ABC multidrug
transporter
MDR3
Tavaborole
Tavaborole
L-Leucine
ATP
AMP
PP
i
tRNA(Leu)
L-Leucyl-
tRNA(Leu)
Fungal Cell
Nailbed
Translation
The inhibition of
leucine-tRNA synthetase
causes the blockage of
protein synthesis in the
mitochondria.
Tavaborole is applied
topically to the infected
nail or nailbed
Fungal cell
Bud of Fungal Cell
A7C99_5311
MDR3
Tavaborole
Tavaborole
L-Leucine
Adenosine
triphosphate
Adenosine
monophosphate
Pyrophosphate
tRNA(Leu)
L-Leucyl-
tRNA(Leu)
A7C99_5311
MDR3
Tavab
Tavab
Leu
ATP
AMP
PP
i
TRNALEU
LLTL
Fungal Cell
Nailbed
Translation
The inhibition of
leucine-tRNA synthetase
causes the blockage of
protein synthesis in the
mitochondria.
Tavaborole is applied
topically to the infected
nail or nailbed
Fungal cell
Bud of Fungal Cell
A7C99_5311
MDR3
Tavab
Tavab
Leu
ATP
AMP
Ppi