SMPDB

Pathway Description

Tavaborole Action Pathway

Homo sapiens

Drug Action Pathway

Created: 2023-01-20

Last Updated: 2023-10-25

Tavaborole is an antifungal agent used to treat onychomycosis, a fungal infection of the nail and nail bed due to Trichophyton rubrum or Trichophyton mentagrophytes infection. Tavaborole functions by inhibiting Leucyl-tRNA synthetase, or LeuRS, an essential fungal enzyme required for protein synthesis and for the catalysis of ATP-dependent ligation of L-leucine to tRNA(Leu). This blocks the protein synthesis in the fungal cell which leads to cell degradation and death.

References

Tavaborole Pathway References

Toledo-Bahena ME, Bucko A, Ocampo-Candiani J, Herz-Ruelas ME, Jones TM, Jarratt MT, Pollak RA, Zane LT: The efficacy and safety of tavaborole, a novel, boron-based pharmaceutical agent: phase 2 studies conducted for the topical treatment of toenail onychomycosis. J Drugs Dermatol. 2014 Sep;13(9):1124-32.

Pubmed: 25226015

Markham A: Tavaborole: first global approval. Drugs. 2014 Sep;74(13):1555-8. doi: 10.1007/s40265-014-0276-7.

Pubmed: 25118637

FDA Approved Drug Products: KERYDIN (tavaborole) topical https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/204427s006lbl.pdf

Liu RJ, Long T, Li H, Zhao J, Li J, Wang M, Palencia A, Lin J, Cusack S, Wang ED: Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond. Nucleic Acids Res. 2020 May 21;48(9):4946-4959. doi: 10.1093/nar/gkaa189.

Pubmed: 32232361

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Pubmed: 29126136

Highlighted elements will appear in red.

Highlight Compounds

	Adenosine monophosphate
	Adenosine triphosphate
	L-Leucine
	Pyrophosphate
	Tavaborole

Highlight Proteins

	ABC multidrug transporter MDR3
	leucine--tRNA ligase

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