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DNA polymerase
catalytic
subunit
Multidrug
resistance-
associated
protein 4
Multidrug
resistance-
associated
protein 4
Solute carrier
organic anion
transporter
family member
1B1
Nucleoside
diphosphate
kinase A
Thymidine
kinase
dGTP
Penciclovir triphosphate
Penciclovir
Penciclovir
Penciclovir
Famciclovir
Famciclovir
Penciclovir monophosphate
PP
i
P
i
H
2
O
Desacetyl Famciclovir
Acetic acid
H
2
O
6-Deoxypenciclovir
Acetic acid
O
2
Hydroxide
Magnesium
Viral Proteins
HHV Infected Cell
Integration
Nucleus
Viral RNA
Viral DNA
Less Viral DNA is
transported into the
nucleus, therefore, less
viral DNA is integrated into
the host DNA.
Transcription
Translation
Less viral proteins
produced, fewer viruses can
form.
Cytosol
Extracellular Space
Penciclovir triphosphate
inhibits the activity of DNA
polymerase by competing with
its substrate dGTP.
Viral DNA
Viral mRNA
Viral mRNA
Hepatic Cell
Cytosol