Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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DNA polymerase Drug transporter ABC transporter, substrate- binding lipoprotein Solute carrier organic anion transporter family member 1B1 Pyruvate kinase isozymes R/L Unknown Cidofovir diphosphate dGTP Cidofovir Cidofovir Cidofovir Brincidofovir Brincidofovir PPi Lipid Viral Proteins Magnesium Potassium Smallpox Infected Cell Integration Nucleus Viral RNA Viral DNA Less Viral DNA is transported into the nucleus, therefore, less viral DNA is integrated into the host DNA. Transcription Translation Less viral proteins produced, fewer viruses can form. Cytosol Cidofovir diphosphate inhibits the activity of DNA polymerase by competing with its substrate dGTP. Viral DNA Viral mRNA Viral mRNA Cidofovir diphosphate also gets incorporated into viral DNA, but since it lacks the 3'-OH group which is needed to form the 5′ to 3′ phosphodiester linkage essential for DNA chain elongation, this causes DNA chain termination, preventing the growth of viral DNA. Hepatic Cell Cytosol
Nucleus OPG071 Unknown CDR20291_0805 SLCO1B1 PKLR Unknown Cidofovir diphosphate dGTP Cidofovir Cidofovir Cidofovir Brincidofovir Brincidofovir Pyrophosphate Lipid Viral Proteins