Quantitative metabolomics services for biomarker discovery and validation.
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Polymerase acidic protein Polymerase basic protein 2 Neuraminidase Multidrug resistance- associated protein 4 Solute carrier organic anion transporter family member 1B1 RNA polymerase Hemagglutinin Neuraminidase Matrix protein 2 Nucleoprotein Non-structural protein 1 Nuclear export protein RNA-directed RNA polymerase catalytic subunit Polymerase basic protein 2 Polymerase acidic protein Polymerase basic protein 2 Polymerase acidic protein Liver carboxylesterase 1 RNA polymerase N-Acetylneuraminic acid Oseltamivir carboxylate Oseltamivir carboxylate Oseltamivir Oseltamivir Calcium Manganese Calcium Manganese Manganese Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Endocytosis Viral RNA Viral mRNA RNA replication Oseltamivir carboxylate inhibits viral neuraminidase, preventing the release of new viral particles into the host body Viral RNA is released from the viral cell and transported into the host nucleus Translation Viral RNA and viral proteins are assembled at the host plasma membrane Assembly Budding & Release Respiratory Epithelial Cell Viral Neuraminidase helps viruses to be released from the plasma membrane of the host cell after budding by cleaving terminal sialic acid resides from glycan structures on the surface of the infected cell. Viral mRNA is translated into various proteins required for viral replication and infection Hepatocyte Cytosol Nucleus Liver
Nucleus PA PB2 NA ABCC4 SLCO1B1 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA CES1 PB1 N- Acetylneuraminic acid Oseltamivir carboxylate Oseltamivir carboxylate Oseltamivir Oseltamivir Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) RNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA Influenza A virus (A/Korea/426/1968(H2N2)) mRNA
PA PB2 NA ABCC4 SLCO1B1 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA CES1 PB1 Neu5Ac Ose car Ose car Agucort Agucort Ca2+ Mn2+ Ca2+ Mn2+ Mn2+ I A v A I A v A I A v A I A v A I A v A I A v A Endocytosis Viral RNA Viral mRNA RNA replication Oseltamivir carboxylate inhibits viral neuraminidase, preventing the release of new viral particles into the host body Viral RNA is released from the viral cell and transported into the host nucleus Translation Viral RNA and viral proteins are assembled at the host plasma membrane Assembly Budding & Release Respiratory Epithelial Cell Viral Neuraminidase helps viruses to be released from the plasma membrane of the host cell after budding by cleaving terminal sialic acid resides from glycan structures on the surface of the infected cell. Viral mRNA is translated into various proteins required for viral replication and infection Hepatocyte Cytosol Nucleus Liver
Nucleus PA PB2 NA ABCC4 SLCO1B1 PB1 HA NA M NP NS NS PB1 PB2 PA PB2 PA CES1 PB1 Neu5Ac Ose car Ose car Agucort Agucort I A v A I A v A I A v A I A v A I A v A I A v A