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MYLK ADCY9 PRKAR1A PRKAR2A PRKCA ADRB2 GNB1 MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 KCNN4 PLCB1 GNAS CALM1 GNB1 GNG12 CACNA2D1 Celiprolol Calcium Calcium Calcium Potassium Potassium Celiprolol Guanosine diphosphate Guanosine triphosphate Adenosine triphosphate cAMP Inositol 1,4,5- trisphosphate Phosphatidylinositol 4,5- bisphosphate Diacylglycerol Guanosine triphosphate Phosphate Phosphate Phosphate Calcium Muscle Contraction Muscle Relaxation
MYLK ADCY9 PRKAR1A PRKAR2A PRKCA ADRB2 GNB1 MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 KCNN4 PLCB1 GNAS CALM1 GNB1 GNG12 CACNA2D1 Celip Ca+ Ca+ Ca+ K+ K+ Celip GDP GTP ATP cAMP Inotp P45P Diacylg GTP Pi Pi Pi Ca2+ Ca+ Mus Con Mus Rel Mg2+ Ca2+ Mn2+ Sarcoplasmic Reticulum Cytosol Vascular Smooth Muscle Cell Celiprolol binds to beta-2 adrenergic receptor. The G protein complex separates into alpha and beta/gamma subunits. GDP is replaced with GTP on the alpha subunit. Activated PKA can phosphorylate calcium activated potassium channels causing potassium efflux and promoting hyperpolarization. Activated PKA phosphorylates the IP3 receptor to reduce its affinity for IP3. Activated PKA phosphorylates phospholipase C. There is an overall decrease in calcium levels in the cytosol. Decreased calcium is unable to bind readily to calmodulin. The inhibition of myosin light chain kinase prevents the synthesis of Myosin LC-P which leads to a high concentration of myosin light chain and muscle relaxation. Myosin unbinds from actin causing the sarcomere filaments to slide leading to muscle relaxation. Relaxation Actin Myosin Celiprolol is administered orally.
MYLK ADCY9 PRKAR1A PRKAR2A PRKCA ADRB2 GNB1 MYL3 MYL3 ITPR1 CACNB1 CACNA1C PPP1CB CALM1 KCNN4 PLCB1 GNAS CALM1 GNB1 GNG12 CACNA2D1 Celip Ca2+ Ca2+ Ca2+ K+ K+ Celip GDP GTP ATP cAMP Inotp P45P Diacylg GTP Pi Pi Pi Ca2+ Mus Con Mus Rel