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Adenylate
cyclase type 9
Myosin light
chain kinase,
smooth muscle
PKA complex
PKA complex
Alpha-2A
adrenergic
receptor
G protein
complex
Myosin LC-P
Myosin light
chain 3
Inositol 1,4,5-
trisphosphate
receptor type 1
Myosin light
chain
phosphatase
Calmodulin
Calmodulin
Epinephrine
Ca
+
Ca
+
ATP
cAMP
Dipivefrin
Ca
+
Muscle
Contraction
Muscle
Relaxation
G(i) protein
signalling
cascade
Magnesium
Calcium
Manganese
Sarcoplasmic Reticulum
Cytosol
Ciliary Smooth Muscle Cell
Epinephrine binds to alpha-2
adrenergic receptor.
Activation of the alpha-2
adrenergic receptor
activates the G(i) protein
signalling cascade.
There is an overall increase
in calcium levels in the
cytosol.
Increased calcium is able to
bind readily to calmodulin.
The high concentration of
myosin LC-P allows for
muscle contraction to occur
Anterior Chamber
Actin
Myosin
Inhibition of adenylyl
cyclase, decreasing the
formation of intracellular
cAMP.
Dipivefrin is a prodrug for
epinephrine.
Dipivefrin is administered
as an eye drop
Myosin binds to actin
causing the sarcomere
filaments to slide leading
to muscle contraction
ADCY9
MYLK
PRKAR1A
PRKAR2A
ADRA2A
GNAI1
MYL3
MYL3
ITPR1
PPP1CB
CALM1
CALM1
Epinephrine
Calcium
Calcium
Adenosine
triphosphate
cAMP
Dipivefrin
Calcium
Muscle
Contraction
Muscle
Relaxation
G(i) protein
signalling
cascade