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Pathway Description
Glutethimide Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-05-25
Last Updated: 2023-10-25
Glutethimide is a hypnotic and sedative. Its use has been largely superseded by other drugs. It can be found under the brand name Doriden and is used to treat insomnia. The hypnotic effect is roughly analogous to that of pentobarbital. It is given to patients who cannot tolerate barbiturates. However, it does not have any advantage over benzodiazepines, and therefore it is rarely used. Glutethimide, like the barbiturates, is a hypnotic sedative. It was introduced in 1954 as a safer alternative to barbiturates but was soon determined to be just as likely to cause addiction and withdrawal symptoms. Glutethimide seems to be a GABA agonist which helps induce sedation by increasing chlorine ion influx leading to hyperpolarization. It also induces CYP 2D6. When taken with codeine, (known on the streets as "hits", "cibas and codeine", "Dors and 4s") it enables the body to convert higher amounts of the codeine to morphine. The general sedative effect of the glutethimide also adds to the effect of the combination. Some side effects of using glutethimide may include blurry vision, skin rash, nausea, and diarrhea.
References
Glutethimide Pathway References
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