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Gamma-
aminobutyric
acid receptor
subunit beta-2
Gamma-
aminobutyric
acid receptor
subunit gamma-2
Gamma-
aminobutyric
acid type B
receptor
Gamma-
aminobutyric
acid receptor
subunit alpha-1
Adenylate
cyclase type 1
Vesicular
inhibitory
amino acid
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Glutamate
decarboxylase 1
γ-Aminobutyric acid
cAMP
γ-Aminobutyric acid
Ca
+
Lormetazepam
L-Glutamic acid
Cl
-
γ-Aminobutyric acid
Ca
+
Lormetazepam
Lormetazepam
Cl
-
CO
2
ATP
PP
i
Magnesium
Pyridoxal
5'-phosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
Hyperpolarization leading to
reduced depolarization and
excitability. Decreasing
neuronal excitability has a
sedative effect
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA binds to the GABA(A)
receptor in between the
alpha and beta subunits.
Lormetazepam binds to an
allosteric site of the
GABA(A) receptor between the
gamma and alpha subunits.
Cytosol
Cytosol
Synapse
Lormetazepam is a ligand for
the GABA(A) benzodiazepine
binding site
Lormetazepam is administered
as an oral tablet
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
γ-Aminobutyric
acid
cAMP
γ-Aminobutyric
acid
Calcium
Lormetazepam
L-Glutamic acid
Chloride ion
γ-Aminobutyric
acid
Calcium
Lormetazepam
Lormetazepam
Chloride ion
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
GABA
cAMP
GABA
Ca
+
Loramet
Glu
Cl
-
GABA
Ca
+
Loramet
Loramet
Cl
-
CO
2
ATP
PP
i
Mg2+
Pyr-5'P
Gi/ sig
PW000003
Hyper
Hyperpolarization leading to
reduced depolarization and
excitability. Decreasing
neuronal excitability has a
sedative effect
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA binds to the GABA(A)
receptor in between the
alpha and beta subunits.
Lormetazepam binds to an
allosteric site of the
GABA(A) receptor between the
gamma and alpha subunits.
Cytosol
Cytosol
Synapse
Lormetazepam is a ligand for
the GABA(A) benzodiazepine
binding site
Lormetazepam is administered
as an oral tablet