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Gamma-
aminobutyric
acid receptor
subunit beta-2
Gamma-
aminobutyric
acid receptor
subunit gamma-2
Gamma-
aminobutyric
acid type B
receptor
Gamma-
aminobutyric
acid receptor
subunit alpha-1
Adenylate
cyclase type 1
Vesicular
inhibitory
amino acid
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Multidrug
resistance-
associated
protein 4
Solute carrier
family 22
member 11
Glutamate
decarboxylase 1
γ-Aminobutyric acid
cAMP
γ-Aminobutyric acid
Ca
+
Nordiazepam
L-Glutamic acid
Cl
-
γ-Aminobutyric acid
Ca
+
Nordiazepam
Prazepam
Prazepam
Prazepam
Cl
-
CO
2
ATP
PP
i
Nordiazepam
Magnesium
Pyridoxal
5'-phosphate
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization
Hyperpolarization leading to
reduced depolarization and
excitability. Decreasing
neuronal excitability has a
sedative effect
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA binds to the GABA(a)
receptor in between the
alpha and beta subunits.
Nordiazepam binds to an
allosteric site of the
GABA(A) receptor between the
gamma and alpha subunits. It
is a ligand for the
benzodiazepine binding site.
Cytosol
Cytosol
Synapse
Hepatocyte
Endoplasmic Reticulum
Prazepam is administered as
an oral tablet
Endoplasmic Reticulum
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
ABCC4
SLC22A11
GAD1
γ-Aminobutyric
acid
cAMP
γ-Aminobutyric
acid
Calcium
Nordiazepam
L-Glutamic acid
Chloride ion
γ-Aminobutyric
acid
Calcium
Nordiazepam
Prazepam
Prazepam
Prazepam
Chloride ion
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Nordiazepam
Gi/o signalling
Glutamate
Metabolism
Hyperpolarization