Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Multidrug resistance- associated protein 4 Solute carrier family 22 member 11 Glutamate decarboxylase 1 3-oxo-5- alpha-steroid 4-dehydrogenase 1 Aldo-keto reductase family 1 member C4 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Brexanolone L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Allopregnanolone Allopregnanolone Cl- CO2 ATP PPi Progesterone 5a-Pregnane-3,20-dione Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(a) receptor in between the alpha and beta subunits. Brexanolone (allopregnanolone) binds to GABA(A) receptor. Cytosol Cytosol Synapse Hepatocyte Endoplasmic Reticulum 5a-reductase converts progesterone to 5a-DHP. 3a-HSD converts 5a-DHP to allopregnanolone. Brexanolone occurs naturally in the body, but can be injected intravenously.
Endoplasmic Reticulum GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A ABCC4 SLC22A11 GAD1 SRD5A1 AKR1C4 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Brexanolone L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Allopregnanolone Allopregnanolone Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Progesterone 5a-Pregnane- 3,20-dione Gi/o signalling Glutamate Metabolism Hyperpolarization