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Gamma-
aminobutyric
acid receptor
subunit beta-2
Gamma-
aminobutyric
acid receptor
subunit gamma-2
Gamma-
aminobutyric
acid type B
receptor
Gamma-
aminobutyric
acid receptor
subunit alpha-1
Adenylate
cyclase type 1
Vesicular
inhibitory
amino acid
transporter
Voltage-
dependent
P/Q-type
calcium channel
subunit
alpha-1A
Glutamate
decarboxylase 1
γ-Aminobutyric acid
cAMP
γ-Aminobutyric acid
Ca
+
Flumazenil
L-Glutamic acid
γ-Aminobutyric acid
Ca
+
Flumazenil
Cl
-
Cl
-
CO
2
ATP
PP
i
Magnesium
Pyridoxal
5'-phosphate
Gi/o signalling
Glutamate
Metabolism
Depolarization
Depolarization leading to
increased excitability.
Increasing neuronal
excitability combats the
sedative effects of
benzodiazepines.
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA(A) receptor site is
competitively inhibited by
Flumazenil.
Flumazenil competitively
inhibits the activity at the
benzodiazepine recognition
site. It targets the
gamma-2, alpha-1, and
alpha-5 subunits.
Cytosol
Cytosol
Synapse
Flumazenil is administered
via intravenous injection
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
γ-Aminobutyric
acid
cAMP
γ-Aminobutyric
acid
Calcium
Flumazenil
L-Glutamic acid
γ-Aminobutyric
acid
Calcium
Flumazenil
Chloride ion
Chloride ion
Carbon dioxide
Adenosine
triphosphate
Pyrophosphate
Gi/o signalling
Glutamate
Metabolism
Depolarization
GABRB2
GABRG2
GABBR2
GABRA1
ADCY1
SLC32A1
CACNA1A
GAD1
GABA
cAMP
GABA
Ca
+
Anexate
Glu
GABA
Ca
+
Anexate
Cl
-
Cl
-
CO
2
ATP
PP
i
Mg2+
Pyr-5'P
Gi/ sig
PW000003
Depol
Depolarization leading to
increased excitability.
Increasing neuronal
excitability combats the
sedative effects of
benzodiazepines.
Presynaptic Neuron
Post Synaptic Neuron
Synaptic Vesicle
GABA(A) receptor site is
competitively inhibited by
Flumazenil.
Flumazenil competitively
inhibits the activity at the
benzodiazepine recognition
site. It targets the
gamma-2, alpha-1, and
alpha-5 subunits.
Cytosol
Cytosol
Synapse
Flumazenil is administered
via intravenous injection