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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Ganaxolone L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Ganaxolone Ganaxolone Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(A) receptor in between the alpha and beta subunits. Ganaxolone binds to an allosteric site of the GABA(A) receptor. Cytosol Cytosol Synapse Ganaxolone is administered as an oral suspension
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Ganaxolone L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Ganaxolone Ganaxolone Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Ganax Glu Cl- GABA Ca+ Ganax Ganax Cl- CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Hyper Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(A) receptor in between the alpha and beta subunits. Ganaxolone binds to an allosteric site of the GABA(A) receptor. Cytosol Cytosol Synapse Ganaxolone is administered as an oral suspension
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca2+ Ganax Glu Cl GABA Ca2+ Ganax Ganax Cl CO2 ATP Ppi Gi/ sig PW000003 Hyper