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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Pentobarbital L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Pentobarbital Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(A) receptor in between the alpha and beta subunits. Pentobarbital binds to the GABA(A) receptor at the binding site associated with the Cl- ionopore. Cytosol Cytosol Synapse Pentobarbital is a potentiator of the GABA(A) alpha-1 through alhpa-6 subunits Pentobarbital is administered via intravenous or intramuscular injection
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Pentobarbital L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Pentobarbital Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca+ Nembuta Glu Cl- GABA Ca+ Nembuta Cl- CO2 ATP PPi Mg2+ Pyr-5'P Gi/ sig PW000003 Hyper Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(A) receptor in between the alpha and beta subunits. Pentobarbital binds to the GABA(A) receptor at the binding site associated with the Cl- ionopore. Cytosol Cytosol Synapse Pentobarbital is a potentiator of the GABA(A) alpha-1 through alhpa-6 subunits Pentobarbital is administered via intravenous or intramuscular injection
GABRB2 GABRG2 GABBR2 GABRA1 ADCY1 SLC32A1 CACNA1A GAD1 GABA cAMP GABA Ca2+ Nembuta Glu Cl GABA Ca2+ Nembuta Cl CO2