Quantitative metabolomics services for biomarker discovery and validation.
Specializing in ready to use metabolomics kits.
Your source for quantitative metabolomics technologies and bioinformatics.
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Gamma- aminobutyric acid receptor subunit beta-2 Gamma- aminobutyric acid receptor subunit gamma-2 Gamma- aminobutyric acid type B receptor Cytochrome P450 Gamma- aminobutyric acid receptor subunit alpha-1 Adenylate cyclase type 1 Vesicular inhibitory amino acid transporter Voltage- dependent P/Q-type calcium channel subunit alpha-1A Solute carrier organic anion transporter family member 1B1 Glutamate decarboxylase 1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Ca+ Stiripentol Stiripentol L-Glutamic acid Cl- γ-Aminobutyric acid Ca+ Stiripentol Stiripentol Cl- CO2 ATP PPi Magnesium Pyridoxal 5'-phosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Drug Metabolism Hyperpolarization leading to reduced depolarization and excitability. Decreasing neuronal excitability has a sedative effect Presynaptic Neuron Post Synaptic Neuron Synaptic Vesicle GABA binds to the GABA(a) receptor in between the alpha and beta subunits. Stiripentol binds to GABA(A) receptor at a receptor site that is not the benzodiazepine site. Cytosol Cytosol Synapse Hepatocyte Endoplasmic Reticulum Stiripentol inhibits cytochrome P450 resulting in increased blood levels of drugs as metabolism is slowed. Stiripentol is administered as an oral tablet
Endoplasmic Reticulum GABRB2 GABRG2 GABBR2 CYP2B6 GABRA1 ADCY1 SLC32A1 CACNA1A SLCO1B1 GAD1 γ-Aminobutyric acid cAMP γ-Aminobutyric acid Calcium Stiripentol Stiripentol L-Glutamic acid Chloride ion γ-Aminobutyric acid Calcium Stiripentol Stiripentol Chloride ion Carbon dioxide Adenosine triphosphate Pyrophosphate Gi/o signalling Glutamate Metabolism Hyperpolarization Drug Metabolism