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Glutamate [NMDA] receptor subunit epsilon-1 Glutamate [NMDA] receptor subunit epsilon-2 Glutamate [NMDA] receptor subunit 3A Vesicular glutamate transporter 3 Voltage- dependent P/Q-type calcium channel subunit alpha-1A Glutaminase kidney isoform, mitochondrial L-Glutamic acid Ca+ L-Glutamic acid Memantine Ca+ L-Glutamine Ca+ L-Glutamic acid Ca+ Memantine Memantine H2O NH3 Depolarization Glutamate Metabolism Cytosol Mematine binds to the Glutamate NMDA receptor which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron Blocking the Glutamate NMDA receptor prevents depolarization of the neuron that is caused by an influx of calcium. Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Glutamate would bind to the subunit epsilon-2 receptor, however since Mematine bound to the glutamate receptor, glutamate is unable to bind in order to open the calcium channel so calcium is unable to enter the neuron Synaptic Vesicle Synapse Blood-Brain Barrier Diffusion
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS L-Glutamic acid Calcium L-Glutamic acid Memantine Calcium L-Glutamine Calcium L-Glutamic acid Calcium Memantine Memantine Water Ammonia Depolarization Glutamate Metabolism
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca+ Glu Memanti Ca+ Gln Ca+ Glu Ca+ Memanti Memanti H2O NH3 Depol PW000003 Cytosol Mematine binds to the Glutamate NMDA receptor which prevents Glutamate from binding and activating the receptor. This prevents depolarization Postsynaptic Neuron Blocking the Glutamate NMDA receptor prevents depolarization of the neuron that is caused by an influx of calcium. Presynaptic Neuron Cytosol Glutamate can be synthesized in the neuron or often is synthesized in adjacent glial cells Glutamate would bind to the subunit epsilon-2 receptor, however since Mematine bound to the glutamate receptor, glutamate is unable to bind in order to open the calcium channel so calcium is unable to enter the neuron Synaptic Vesicle Synapse Blood-Brain Barrier Diffusion
GRIN2A GRIN2B GRIN3A SLC17A8 CACNA1A GLS Glu Ca2+ Glu Memanti Ca2+ Gln Ca2+ Glu Ca2+ Memanti Memanti H2O NH3 Depol PW000003