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Pathway Description
Flumethasone Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-06
Last Updated: 2023-10-25
Flumethasone is a difluorinated corticosteroid used to treat contact dermatitis, atopic dermatitis, eczema, psoriasis, diaper rash, and other skin conditions. As it is a privalate salt, its anti-inflammatory action stays at the site of application. Flumethasone is a glucocorticoid receptor agonist. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Flumethasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation. Flumethasone is administered as an auricular solution or as a topical cream or ointment.
References
Flumethasone Pathway References
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