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Pathway Description
Fluticasone Action Pathway
Homo sapiens
Drug Action Pathway
Created: 2023-06-07
Last Updated: 2023-10-25
Fluticasone is a corticosteroid used in the treatment of corticosteroid-responsive dermatoses, asthma, and moderate to severe Chronic Obstructive Pulmonary Disease (COPD). Fluticasone is a synthetic glucocorticoid available as 2 esters, Fluticasone furoate, and Fluticasone propionate. It is available as an inhaler, nasal spray, and topical cream. As this molecule is a glucocorticoid, its mechanism of action is that of the glucocorticoid response element (GRE) of influencing COX-2/prostaglandin G/H synthase 2 suppression and lipocortin/annexin induction. By binding to the glucocorticoid receptor, it influences transcription factors AP-1 and NF-kB to block the transcription of COX-2/prostaglandin G/H synthase 2 which reduces the amount of prostanoids being produced from arachidonic acid. Prostanoids such as PGI2 and thromboxane A2 influence the effects of inflammation through vasoconstriction/dilation, pain sensitivity, and platelet aggregation. Fluticasone also affects the promoter of annexin-1, an important inflammatory protein as it affects leukocytes and blocks phospholipase A2 which reduces the amount of arachidonic acid being cleaved from the phospholipid bilayer. Reducing the amount of arachidonic acid formed further decreases the concentrations of prostanoids mentioned calming inflammation.
References
Fluticasone Pathway References
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